Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non-Help-Seeking Population.
Correlation Between Levels of Delusional Beliefs and Perfusion of the Hippocampus and an Associated Network in a Non-Help-Seeking Population.
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DOI：
10.1016/j.bpsc.2017.06.007
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Holt DJ
中科院分区：
文献类型：
--
作者：
Wolthusen RPF;Coombs G 3rd;Boeke EA;Ehrlich S;DeCross SN;Nasr S;Holt DJ
妄想症是精神病的一种典型且常见的症状。最近的证据表明，亚临床和临床妄想可能代表着现象学和生物学连续体上的不同阶段。然而，很少有研究测试亚临床精神病经历是否与神经变化有关，这些变化与临床精神病中观察到的类似。例如，目前尚不清楚精神分裂症的神经成像研究中重复发现的海马体过度活动是否也存在于有亚临床精神病症状的个人身上。为了研究这个问题，收集了77名没有精神病史的成年参与者的结构性和脉冲式动脉自旋标记扫描。使用解剖感兴趣区方法从每个个体提取海马体和其他15个区域的静息灌注。在扫描当天收集妄想自评量表。妄想性思维的水平(信念的数量[r=0.27，p=0.02])以及与之相关的痛苦水平(r=0.29，p=0.02)与海马区的灌注量(左右半球的平均值)显著相关。在控制了年龄、海马体体积、抑郁和焦虑症状以及图像信噪比后，相关性仍然显著，并在体素回归分析中得到证实。在丘脑和海马旁、外侧颞叶和扣带回皮质也观察到了同样的关联。与精神分裂症患者类似，未寻求帮助的个体表现出边缘区域网络的灌注率升高，这与妄想信念有关。
Delusions are a defining and common symptom of psychotic disorders. Recent evidence suggests that subclinical and clinical delusions may represent distinct stages on a phenomenological and biological continuum. However, few studies have tested whether subclinical psychotic experiences are associated with neural changes that are similar to those observed in clinical psychosis. For example, it is unclear if overactivity of the hippocampus, a replicated finding of neuroimaging studies of schizophrenia, is also present in individuals with subclinical psychotic symptoms. To investigate this question, structural and pulsed arterial spin labeling scans were collected in 77 adult participants with no psychiatric history. An anatomical region of interest approach was used to extract resting perfusion of the hippocampus, and 15 other regions, from each individual. A self-report measure of delusional ideation was collected on the day of scanning. The level of delusional thinking (number of beliefs [r = .27, p = .02]), as well as the associated level of distress (r = .29, p = .02), was significantly correlated with hippocampal perfusion (averaged over right and left hemispheres). The correlations remained significant after controlling for age, hippocampal volume, symptoms of depression and anxiety, and image signal-to-noise ratio, and they were confirmed in a voxelwise regression analysis. The same association was observed in the thalamus and parahippocampal, lateral temporal, and cingulate cortices. Similar to patients with schizophrenia, non–help-seeking individuals show elevated perfusion of a network of limbic regions in association with delusional beliefs.
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