Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots.
Cadmium-containing nanoparticles: perspectives on pharmacology and toxicology of quantum dots.
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DOI：
10.1016/j.taap.2009.04.010
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发表时间：
2009-08-01
影响因子：
3.8
通讯作者：
Strobl JS
中科院分区：
文献类型：
--
作者：
Rzigalinski BA;Strobl JS
随着具有彻底改变医疗潜力的新型纳米药物的开发，纳米技术领域正在迅速扩大。该领域的快速扩展速度已经超过了纳米颗粒在生物环境中的作用的药理和毒理学研究的速度。含镉纳米颗粒（称为量子点）的开发，由于其尺寸可调的荧光和易于组织靶向的功能化，在癌症的治疗和诊断以及靶向药物输送方面显示出巨大的前景。然而，有关量子点药理学和毒理学的信息需要进一步发展，因此很难评估与这种新纳米技术相关的风险。此外，纳米技术还带来了有毒镉的另一个风险，镉现在将以纳米形式进入生物领域。在这篇综述中，我们讨论了含镉量子点及其在纳米尺度上的物理化学性质。我们总结了含镉量子点药理学和毒理学的现有工作，并讨论了其在疾病治疗中的应用前景。最后，我们确定了我们对镉量子点毒性知识的关键差距，以及如何评估这些差距以使量子点纳米技术能够安全地从实验室转移到临床。
The field of nanotechnology is rapidly expanding with the development of novel nanopharmaceuticals that have potential for revolutionizing medical treatment. The rapid pace of expansion in this field has exceeded the pace of pharmacological and toxicological research on the effects of nanoparticles in the biological environment. The development of cadmium-containing nanoparticles, known as quantum dots, show great promise for treatment and diagnosis of cancer and targeted drug delivery, due to their size-tunable fluorescence and ease of functionalization for tissue targeting. However information on pharmacology and toxicology of quantum dots needs much further development, making it difficult to assess the risks associated with this new nanotechnology. Further, nanotechnology poses yet another risk for toxic cadmium, which will now enter the biological realm in nano-form. In this review, we discuss cadmium-containing quantum dots and their physicochemical properties at the nano-scale. We summarize the existing work on pharmacology and toxicology of cadmium-containing quantum dots and discuss perspectives in their utility in disease treatment. Finally, we identify critical gaps in our knowledge of cadmium quantum dot toxicity, and how these gaps need to be assessed to enable quantum dot nanotechnology to transit safely from bench to bedside.
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影响因子：
10.4
作者：
Hardman R
通讯作者：
Hardman R
DOI：
10.1080/15287390801989218
发表时间：
2008-01-01
影响因子：
2.6
作者：
Bhattacharya, K.;Cramer, H.;Dopp, E.
通讯作者：
Dopp, E.
影响因子：
4.7
作者：
Choi, Angela O.;Brown, Shelley E.;Maysinger, Dusica
通讯作者：
Maysinger, Dusica
DOI：
10.1073/pnas.152463399
发表时间：
2002-10-01
影响因子：
11.1
作者：
Åkerman, ME;Chan, WCW;Ruoslahti, E
通讯作者：
Ruoslahti, E
影响因子：
46.9
作者：
Jaiswal, JK;Mattoussi, H;Simon, SM
通讯作者：
Simon, SM