The balance between leptin and adiponectin in the control of carcinogenesis - focus on mammary tumorigenesis.
The balance between leptin and adiponectin in the control of carcinogenesis - focus on mammary tumorigenesis.
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DOI：
10.1016/j.biochi.2012.06.013
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发表时间：
2012-10
期刊：
影响因子：
3.9
通讯作者：
Cleary, Margot R.
中科院分区：
文献类型：
--
作者：
Grossmann, Michael E.;Cleary, Margot R.
许多研究表明，越来越多的癌症可能受到肥胖的影响。在肥胖个体中，这些癌症可能更频繁，更具侵略性，导致生存率降低。在这方面，最突出和最具特征的癌症之一是乳腺癌。肥胖在乳腺癌中起着复杂的作用，并且与炎症增加、血管生成和血清中潜在生长因子（如血清中的脂联素、瘦素和雌激素）水平的改变相关。据报道，与健康对照组相比，乳腺癌患者血清脂联素水平降低，尤其是绝经后妇女。血清瘦素水平在乳腺癌中的作用似乎更为复杂。一些研究表明瘦素在乳腺癌患者中增加，但其他研究发现瘦素减少或不变。这可能是由于一些混淆的问题。我们和其他人认为脂联素和瘦素的水平以及脂联素和瘦素的平衡可能是乳腺癌和其他肥胖相关癌症肿瘤发生的关键因素。
A number of studies indicate that a growing list of cancers may be influenced by obesity. In obese individuals these cancers can be more frequent and more aggressive resulting in reduced survival. One of the most prominent and well characterized cancers in this regard is breast cancer. Obesity plays a complex role in breast cancer and is associated with increased inflammation, angiogenesis and alterations in serum levels of potential growth factors such as adiponectin, leptin and estrogen in the serum. Reduced levels of serum adiponectin have been reported in breast cancer patients compared to healthy controls, particularly in postmenopausal women. The role of serum leptin levels in breast cancer appears to be more complex. Some studies have shown leptin to be increased in women with breast cancer but other studies have found leptin to be decreased or unchanged. This may be due to a number of confounding issues. We and others propose that it may be the levels of adiponectin and leptin as well as the balance of adiponectin and leptin that are the critical factors in breast and other obesity related cancer tumorigenesis.
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影响因子：
5.8
作者：
Dal Maso, L;Augustin, LSA;La Vecchia, C
通讯作者：
La Vecchia, C
DOI：
10.1016/j.bbrc.2006.04.076
发表时间：
2006-06-23
影响因子：
3.1
作者：
Dieudonne, Marie-Noelle;Bussiere, Marianne;Pecquery, Rene
通讯作者：
Pecquery, Rene
影响因子：
4.9
作者：
Cleary, MP;Grande, JP;Maihle, NJ
通讯作者：
Maihle, NJ
DOI：
10.1186/1756-9966-30-21
发表时间：
2011-02-21
影响因子：
11.3
作者：
Amjadi, Fatemehsadat;Javanmard, Shaghaygh Haghjooy;Narimani, Manijeh
通讯作者：
Narimani, Manijeh
影响因子：
2.2
作者：
Arditi, J. D.;Venihaki, M.;Chrousos, G. P.
通讯作者：
Chrousos, G. P.