Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy.
Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy.
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妊娠期间宫颈基质的机械性能与细胞外基质成分之间的关系。
DOI：
10.1053/j.semperi.2009.06.002
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发表时间：
2009-10
影响因子：
3.4
通讯作者：
Socrate S
中科院分区：
文献类型：
--
作者：
House M;Kaplan DL;Socrate S
在正常妊娠期间，在胎儿和子宫大幅生长的过程中，宫颈保持其形状。因此，维持生物力学完整性是宫颈功能的一个重要方面。已知宫颈的力学特性源于细胞外基质。宫颈细胞外基质最重要的成分是纤维状胶原蛋白——宫颈正是从胶原蛋白中获得其“强度”。已知其他影响胶原蛋白网络的基质分子包括水、蛋白聚糖、透明质酸和弹性蛋白。本综述的目的是讨论生化成分与宏观力学特性之间的关系。将讨论细胞外基质的各个成分，特别是关于妊娠期胶原蛋白的重塑。此外，还将综述宫颈组织的宏观力学特性。更好地理解宫颈“强度”的生物化学原理，将有助于阐明宫颈在正常妊娠中如何保持其形状以及在早产时如何缩短。
In normal pregnancy, the cervix maintains its shape during a period of substantial fetal and uterine growth. Hence, maintenance of biomechanical integrity is an important aspect of cervical function. It is known that cervical mechanical properties arise from the extracellular matrix. The most important constituent of the cervical extracellular matrix is fibrillar collagen – it is from collagen protein that the cervix derives its “strength.” Other matrix molecules known to affect the collagen network include water, proteoglycans, hyaluronan and elastin. The objective of this review is to discuss relationships between biochemical constituents and macroscopic mechanical properties. The individual constituents of the extracellular matrix will be discussed, especially in regard to collagen remodeling during pregnancy. In addition, the macroscopic mechanical properties of cervical tissue will be reviewed. An improved understanding of the biochemistry of cervical “strength” will shed light into how the cervix maintains its shape in normal pregnancy and shortens in preterm birth.
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影响因子：
9.8
作者：
Gomez, R;Romero, R;Gonzalez, R
通讯作者：
Gonzalez, R
DOI：
10.1016/0006-2944(79)90081-4
发表时间：
1979-01-01
期刊：
BIOCHEMICAL MEDICINE
影响因子：
--
作者：
ITO, A;KITAMURA, K;HIRAKAWA, S
通讯作者：
HIRAKAWA, S
DOI：
10.1016/j.ejogrb.2006.10.006
发表时间：
2007-10-01
期刊：
EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY
影响因子：
--
作者：
Anthony, George S.;Walker, Robert G.;Calder, Andrew A.
通讯作者：
Calder, Andrew A.
DOI：
10.1111/j.1471-0528.1989.tb03196.x
发表时间：
1989-10-01
期刊：
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY
影响因子：
--
作者：
GRANSTROM, L;EKMAN, G;MALMSTROM, A
通讯作者：
MALMSTROM, A
DOI：
10.1016/j.ejogrb.2005.03.006
发表时间：
2005-11-01
影响因子：
2.6
作者：
Fittkow, CT;Maul, H;Garfield, RE
通讯作者：
Garfield, RE