The Mouse Genome Database (MGD): mouse biology and model systems.
The Mouse Genome Database (MGD): mouse biology and model systems.
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DOI：
10.1093/nar/gkm961
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发表时间：
2008-01
影响因子：
14.9
通讯作者：
Mouse Genome Database Group
中科院分区：
文献类型：
--
作者：
Bult CJ;Eppig JT;Kadin JA;Richardson JE;Blake JA;Mouse Genome Database Group
小鼠基因组数据库（MGD，http：//www.informatics.jax.org/）整合了关于实验室小鼠的遗传、基因组和表型信息，实验室小鼠是研究人类生物学和疾病的主要动物模型。MGD数据内容包括基因及其功能的全面表征、小鼠表型的标准化描述、DNA和蛋白质序列数据的广泛整合、基因组和基因组变异信息的标准化表示，包括哺乳动物基因的比较数据。MGD中的数据来自不同的来源，包括生物医学文献的手动管理，个人研究者实验室和主要信息资源中心（如Ensembl，UniProt和NCBI）的直接贡献。MGD与生物信息学社区合作开发数据和语义标准，如基因本体论（GO）和哺乳动物表型（MP）本体论。MGD提供了一个数据挖掘平台，可以基于比较基因型，表型和功能分析开发转化研究假设。提供了基于Web的查询和对数据的计算访问。这里描述的MGD的最新改进包括基因陷阱数据与小鼠基因的关联以及用于定制数据访问和检索的新的批量查询能力。
The Mouse Genome Database, (MGD, http://www.informatics.jax.org/), integrates genetic, genomic and phenotypic information about the laboratory mouse, a primary animal model for studying human biology and disease. MGD data content includes comprehensive characterization of genes and their functions, standardized descriptions of mouse phenotypes, extensive integration of DNA and protein sequence data, normalized representation of genome and genome variant information including comparative data on mammalian genes. Data within MGD are obtained from diverse sources including manual curation of the biomedical literature, direct contributions from individual investigator's laboratories and major informatics resource centers such as Ensembl, UniProt and NCBI. MGD collaborates with the bioinformatics community on the development of data and semantic standards such as the Gene Ontology (GO) and the Mammalian Phenotype (MP) Ontology. MGD provides a data-mining platform that enables the development of translational research hypotheses based on comparative genotype, phenotype and functional analyses. Both web-based querying and computational access to data are provided. Recent improvements in MGD described here include the association of gene trap data with mouse genes and a new batch query capability for customized data access and retrieval.
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