Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation.
Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation.
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DOI：
10.1371/journal.pcbi.1009235
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发表时间：
2021-07
影响因子：
4.3
通讯作者：
Zochowski M
中科院分区：
文献类型：
--
作者：
Yang Y;Gritton H;Sarter M;Aton SJ;Booth V;Zochowski M
Theta和gamma节律及其交叉频率耦合在感知、注意力、学习和记忆中起着至关重要的作用。现有数据表明，前脑乙酰胆碱（ACh）信号传导促进theta-gamma偶联，尽管其机制尚未确定。最近的证据表明，与传统的缓慢、空间均匀和弥漫性神经调节的概念相反，胆碱能信号传导在时间和空间上都受到限制。在这里，我们发现空间受限的胆碱能刺激可以产生theta调节的gamma节律。利用基于生物物理的兴奋-抑制（E-I）神经网络模型，我们通过改变毒蕈碱受体调节的K+电流的电导来模拟ACh对神经兴奋性的影响。在具有局部兴奋性连接和全局抑制性连接的E-I网络中，我们证明了在ACh调节的网络区域中出现了theta-gamma耦合的放电模式。稳定的伽马调制放电发生在ACh信号高的区域，而theta或混合theta-gamma活动发生在这些区域的外围。高伽马活动也在不同的高乙酰胆碱区域之间交替，在θ频率上。我们的研究结果首次表明空间异质性乙酰胆碱信号在局部theta-gamma节律性出现中的因果作用。我们的发现也为乙酰胆碱信号支持大脑区域特异性注意处理感觉信息的机制提供了新的见解。最近的证据表明，乙酰胆碱信号传递是短暂的和空间限制的，这提出了这个特征如何影响皮质网络中的信息处理的问题。在这里，我们证明了空间分离的兴奋抑制性神经网络的ACh调制产生了theta调制的伽马节律，这是注意力和信息处理的标志。当神经元活动穿过网络的高乙酰氨基酚区域时，theta -gamma耦合自然产生，并且gamma活动在theta频率下不同的高乙酰氨基酚位点之间交替。这些发现为乙酰胆碱调节的θ - γ偶联和解耦的神经生理机制提供了新的见解。
Theta and gamma rhythms and their cross-frequency coupling play critical roles in perception, attention, learning, and memory. Available data suggest that forebrain acetylcholine (ACh) signaling promotes theta-gamma coupling, although the mechanism has not been identified. Recent evidence suggests that cholinergic signaling is both temporally and spatially constrained, in contrast to the traditional notion of slow, spatially homogeneous, and diffuse neuromodulation. Here, we find that spatially constrained cholinergic stimulation can generate theta-modulated gamma rhythms. Using biophysically-based excitatory-inhibitory (E-I) neural network models, we simulate the effects of ACh on neural excitability by varying the conductance of a muscarinic receptor-regulated K+ current. In E-I networks with local excitatory connectivity and global inhibitory connectivity, we demonstrate that theta-gamma-coupled firing patterns emerge in ACh modulated network regions. Stable gamma-modulated firing arises within regions with high ACh signaling, while theta or mixed theta-gamma activity occurs at the peripheries of these regions. High gamma activity also alternates between different high-ACh regions, at theta frequency. Our results are the first to indicate a causal role for spatially heterogenous ACh signaling in the emergence of localized theta-gamma rhythmicity. Our findings also provide novel insights into mechanisms by which ACh signaling supports the brain region-specific attentional processing of sensory information. Recent evidence indicating that ACh signaling is both transient and spatially circumscribed raises the question of how this feature impacts information processing in cortical networks. Here we demonstrate that spatially segregated ACh modulation of excitatory-inhibitory neural networks generates theta-modulated gamma rhythms, a hallmark of attention and information processing. Theta-gamma coupling arises naturally as neuronal activity traverses high-ACh regions of the network, and gamma activity alternates between distinct high-ACh sites at theta frequency. These findings provide novel insights into neurophysiological mechanisms for ACh-regulated theta-gamma coupling and uncoupling.
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影响因子：
16.2
作者：
Bosman CA;Schoffelen JM;Brunet N;Oostenveld R;Bastos AM;Womelsdorf T;Rubehn B;Stieglitz T;De Weerd P;Fries P
通讯作者：
Fries P
影响因子：
5.3
作者：
Disney, Anita A.;Higley, Michael J.
通讯作者：
Higley, Michael J.
DOI：
10.1073/pnas.1516134113
发表时间：
2016-02-23
影响因子：
11.1
作者：
Gritton, Howard J.;Howe, William M.;Sarter, Martin
通讯作者：
Sarter, Martin
影响因子：
2.9
作者：
Boergers, Christoph;Kopell, Nancy J.
通讯作者：
Kopell, Nancy J.
影响因子：
2.9
作者：
Crook, SM;Ermentrout, GB;Bower, JM
通讯作者：
Bower, JM