Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia.
Investigation of sensory thresholds in Cavalier King Charles Spaniels with and without Chiari-like malformations and syringomyelia.
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DOI：
10.1111/jvim.15297
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发表时间：
2018-11
影响因子：
2.6
通讯作者：
Olby NJ
中科院分区：
文献类型：
--
作者：
Sparks CR;Gorney A;Williams K;Griffith EH;Cerda-Gonzalez S;Lascelles BDX;Olby NJ
骑士查理王犬（CKCS）患有与基亚里样畸形和脊髓灰质炎（CMSM）相关的疼痛。人们患有类似的疾病，并描述了许多感官异常。尚未量化受影响CKCS的感觉变化。使用定量感觉测试（QST）来量化CKCS的热阈值和机械阈值，并比较有和无脊髓灰质炎（SM）犬的QST。44个CKCS前瞻性研究。对犬进行神经系统检查和颅脑磁共振成像（MRI）。在肱骨和胸部（n = 32）上进行热测试;在爪和颈部（n = 44）上进行机械测试。将潜伏期、阈值和反应率与MRI上SM的存在和严重程度、主人报告的疼痛的存在和检查时确定的疼痛进行比较。30只犬有SM，30只在检查时疼痛，29只犬主人报告有症状。根据SM的存在或严重程度，热和机械变量没有显著差异。与爪（0.60 kg，SD = 0.30）和颈部（2.72 kg，SD = 0.57; P = 0.021）检查时无疼痛的犬的阈值相比，检查时疼痛的犬爪（0.38 kg，SD = 0.18）和颈部（2.05 kg，SD = 0.74）的机械阈值降低。机械和热敏感性似乎与SM的存在无关，但机械敏感性似乎与疼痛和临床体征的存在相关。机械测试可能有助于评估临床试验期间的感觉异常。
Cavalier King Charles Spaniels (CKCS) suffer pain associated with Chiari‐like malformation and syringomyelia (CMSM). People suffer from a similar condition and describe numerous sensory abnormalities. Sensory changes have not been quantified in affected CKCS. To use quantitative sensory testing (QST) to quantify thermal and mechanical thresholds in CKCS and to compare QST in dogs with and without syringomyelia (SM). Forty‐four CKCS. Prospective study. Dogs underwent neurological examinations and craniocervical magnetic resonance imaging (MRI). Thermal testing was performed over the humerus and thorax (n = 32); mechanical testing was performed on the paw and neck (n = 44). Latencies, thresholds, and response rates were compared with presence and severity of SM on MRI, presence of pain reported by the owner and pain identified on examination. Thirty dogs had SM, 30 were painful on examination, 29 were owner‐reported symptomatic. Thermal and mechanical variables were not significantly different based on presence or severity of SM. Dogs with pain on examination had decreased mechanical thresholds on the paw (0.38 kg, SD = 0.18) and neck (2.05 kg, SD = 0.74) compared to thresholds of dogs without pain on examination on the paw (0.60 kg, SD = 0.30) and neck (2.72 kg, SD = 0.57; P = .021). Mechanical and thermal sensitivity does not appear to be related to the presence of SM, but mechanical sensitivity appears to be related to the presence of pain and clinical signs. Mechanical testing may be useful for assessing sensory abnormalities during clinical trials.
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影响因子：
7.4
作者：
Knazovicky D;Helgeson ES;Case B;Gruen ME;Maixner W;Lascelles BDX
通讯作者：
Lascelles BDX
影响因子：
1.6
作者：
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通讯作者：
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影响因子：
2.2
作者：
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通讯作者：
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影响因子：
1.6
作者：
Rusbridge, C.;Carruthers, H.;Jeffery, N. D.
通讯作者：
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影响因子：
16.2
作者：
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通讯作者：
Basbaum AI