Movement decline across lifespan of Caenorhabditis elegans mutants in the insulin/insulin-like signaling pathway.
Movement decline across lifespan of Caenorhabditis elegans mutants in the insulin/insulin-like signaling pathway.
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DOI：
10.1111/acel.12704
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发表时间：
2018-03
期刊：
影响因子：
7.8
通讯作者：
Johnson TE
中科院分区：
文献类型：
--
作者：
Newell Stamper BL;Cypser JR;Kechris K;Kitzenberg DA;Tedesco PM;Johnson TE
衰老生物学的研究已经确定了几条在不同物种之间分子上保守的途径，这些途径在突变时可以延长寿命。胰岛素/胰岛素样信号通路(IIS)是其中研究最广泛的途径之一。人们一直认为，延长寿命也会延长健康寿命(功能损失最小的寿命)。然而，支持这一假设的数据与最近的证据相互矛盾，表明寿命延长本身可能会延长脆弱的时期。在这项研究中，我们使用秀丽隐杆线虫来进一步探索寿命和健康之间的联系。使用运动减少作为健康的衡量标准，我们评估了九个IIS途径突变的整个生命周期的健康跨度。在一系列实验中，我们研究了大众文化中的健康寿命，在另一系列实验中，我们纵向研究了个体。我们发现，长寿突变体表现出延长的中年运动，而不会延长脆弱期。最后，我们观察到，在相同的表型中，成年早期的运动并不能预测晚年的运动或存活。总体而言，这些观察表明，延长寿命并不会延长脆弱的时期。基因和随机成分都能调节衰老，生命后期的运动比生命早期的运动更具变异性。
Research in aging biology has identified several pathways that are molecularly conserved across species that extend lifespan when mutated. The insulin/insulin‐like signaling (IIS) pathway is one of the most widely studied of these. It has been assumed that extending lifespan also extends healthspan (the period of life with minimal functional loss). However, data supporting this assumption conflict and recent evidence suggest that life extension may, in and of itself, extend the frail period. In this study, we use Caenorhabditis elegans to further probe the link between lifespan and healthspan. Using movement decline as a measure of health, we assessed healthspan across the entire lifespan in nine IIS pathway mutants. In one series of experiments, we studied healthspan in mass cultures, and in another series, we studied individuals longitudinally. We found that long‐lived mutants display prolonged mid‐life movement and do not prolong the frailty period. Lastly, we observed that early‐adulthood movement was not predictive of late‐life movement or survival, within identical phenotypes. Overall, these observations show that extending lifespan does not prolong the period of frailty. Both genotype and a stochastic component modulate aging, and movement late in life is more variable than early‐life movement.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
DOI：
10.1073/pnas.0400848101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Huang, C;Xiong, CJ;Kornfeld, K
通讯作者：
Kornfeld, K
影响因子：
7.8
作者：
McElwee, J;Bubb, K;Thomas, JH
通讯作者：
Thomas, JH
影响因子：
64.8
作者：
Herndon, LA;Schmeissner, PJ;Driscoll, M
通讯作者：
Driscoll, M
影响因子：
56.9
作者：
Arantes-Oliveira, N;Berman, JR;Kenyon, C
通讯作者：
Kenyon, C