Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits.
Increasing stimulus duration can normalize late-positive event related potentials in people with schizophrenia: Possible implications for understanding cognitive deficits.
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DOI：
10.1016/j.schres.2014.07.012
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发表时间：
2014-09
影响因子：
4.5
通讯作者：
Corbera, Silvia
中科院分区：
文献类型：
--
作者：
Wexler, Bruce E.;Ikezawa, Satoru;Corbera, Silvia
本研究旨在确定是否增加刺激持续时间的精神分裂症患者的正常化与调制的情绪诱发刺激反应的晚期事件相关电位（ERP）。这些ERPs降低患者与健康controls.Subjects看到相同的持续时间的刺激时，观察图片的手，并判断所描绘的事件是痛苦的或非痛苦的。图片呈现给患者500或800毫秒，健康对照200或500毫秒。参与者是19名符合DSM-IV精神分裂症或情感障碍标准的成年门诊患者和18名健康对照者，由结构化临床访谈评估。在刺激开始后的350- 900 ms窗口期间对中性刺激的ERP从对疼痛刺激的相同反应窗口期间的ERP中减去。该差异波下的面积反映了疼痛相关阳性的程度，并且是用于分析的依赖性测量。500和800 ms刺激后患者的迟发阳性ERP反应与健康对照分别在200和500 ms刺激后的反应高度相似。当对500 ms刺激的反应进行比较时，患者和对照组差异显着。众所周知，精神分裂症患者处理信息的速度比健康人慢。我们的研究结果表明，感觉输入的早期处理速度减慢可能会限制精神分裂症患者更高的认知和调节过程的参与。这可能是患者自我调节能力受损的原因之一，也可能有助于解释为什么信息处理速度减慢的措施会导致精神分裂症患者其他认知缺陷的差异。
This study determined whether increasing stimulus duration for patients with schizophrenia normalized late Event Related Potentials (ERPs) associated with modulation of response to emotion-evoking stimuli. These ERPs are decreased in patients versus healthy controls when both view stimuli of the same duration.Subjects viewed pictures of hands and judged whether the events depicted were painful or non-painful. Pictures were presented to patients for 500 or 800ms and to healthy controls for 200 or 500ms. Participants were 19 adult outpatients meeting DSM-IV criteria for schizophrenia or schizoaffective disorder and 18 healthy controls, as assessed by the Structured Clinical Interview. ERPs to neutral stimuli during a 350-900ms window following stimulus onset were subtracted from ERPs during this same response window to pain stimuli. The area under this difference wave reflected the degree of pain-related positivity and was the dependent measure for analysis. Patient late-positive ERP responses following 500 and 800ms stimuli were highly similar to responses in healthy controls following 200 and 500ms stimuli respectively. Patients and controls differed significantly when responses to 500ms stimuli were compared. People with schizophrenia are known to process information more slowly than healthy people. Our results indicate that slowed early processing of sensory input may limit engagement of higher cognitive and regulatory processes in patients with schizophrenia. This may be one reason self-regulation is compromised in patients, and may help explain why measures of slowed information processing account for so much variance in other cognitive deficits in schizophrenia.
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