Nucleic acids for the rational design of reaction circuits.

Nucleic acids for the rational design of reaction circuits.
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用于合理设计反应回路的核酸。

DOI:
10.1016/j.copbio.2012.11.011
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发表时间:
2013
影响因子:
7.7
通讯作者:
Y. Rondelez
Y. Rondelez
中科院分区:
工程技术1区
文献类型:
--
作者:
Adrien Padirac;T. Fujii;Y. Rondelez

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基于核酸的电路是合理设计的体外组件,可以执行复杂的预编码程序。它们可用于模拟计算机计算。最近的工作强调了这些电路的模块化和鲁棒性,这使得它们能够按比例放大。另一项新的发展催生了动态的、时间响应的系统,可以表现出振荡等突发行为。这些与生物结构密切相关,并提供体内信息处理的体外模型。核酸回路已被用于处理用于技术或生物技术目的的各种过程。这些化学智能系统的未来应用将受益于设计、构建和建模不断增大的核酸电路的能力的快速增长。
Nucleic acid-based circuits are rationally designedin vitroassemblies that can perform complex preencoded programs. They can be used to mimicin silicocomputations. Recent works emphasized the modularity and robustness of these circuits, which allow their scaling-up. Another new development has led to dynamic, time-responsive systems that can display emergent behaviors like oscillations. These are closely related to biological architectures and provide anin vitromodel ofin vivoinformation processing. Nucleic acid circuits have already been used to handle various processes for technological or biotechnological purposes. Future applications of these chemical smart systems will benefit from the rapidly growing ability to design, construct, and model nucleic acid circuits of increasing size.
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