Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.
Comparisons of resting-state brain activity between insomnia and schizophrenia: a coordinate-based meta-analysis.
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失眠和精神分裂症静息态大脑活动的比较：基于坐标的荟萃分析
DOI：
10.1038/s41537-022-00291-3
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发表时间：
2022-10-07
期刊：
影响因子：
--
通讯作者：
Lui, Su
中科院分区：
文献类型：
--
作者：
Gao, Ziyang;Xiao, Yuan;Zhang, Ye;Zhu, Fei;Tao, Bo;Tang, Xiangdong;Lui, Su
越来越多的证据表明，失眠与精神分裂症(SCZ)密切相关，但这种关联下的神经机制尚不清楚。对静息状态大脑活动模式的直接比较将有助于理解上述问题。运用Meta分析方法，包括11项失眠与健康对照(HC)研究和39项SCZ与健康对照研究，以阐明失眠与SCZ之间的共同和不同模式。结果显示，SCZ和失眠患者的额叶边缘结构包括右侧前额内侧回(MPFC)和左侧海马区旁回的静息状态脑活动增加。此外，SCZ还显示双侧壳核、尾状核和右侧脑岛等皮质下区域的活动显著增加，中央前回和眶前回的活动显著减少。我们的研究揭示了SCZ和失眠的共同和不同的激活模式，这可能为理解这两种疾病的神经基础提供新的见解，并为未来SCZ失眠的治疗策略的制定提供可能。
Growing evidence shows that insomnia is closely associated with schizophrenia (SCZ), but the neural mechanism under the association remains unclear. A direct comparison of the patterns of resting-state brain activities would help understand the above question. Using meta-analytic approach, 11 studies of insomnia vs. healthy controls (HC) and 39 studies of SCZ vs. HC were included to illuminate the common and distinct patterns between insomnia and SCZ. Results showed that SCZ and insomnia shared increased resting-state brain activities in frontolimbic structures including the right medial prefrontal gyrus (mPFC) and left parahippocampal gyrus. SCZ additionally revealed greater increased activities in subcortical areas including bilateral putamen, caudate and right insula and greater decreased activities in precentral gyrus and orbitofrontal gyrus. Our study reveals both shared and distinct activation patterns in SCZ and insomnia, which may provide novel insights for understanding the neural basis of the two disorders and enlighten the possibility of the development of treatment strategies for insomnia in SCZ in the future.
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作者：
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DOI：
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发表时间：
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