Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
Sleep Abnormalities in Schizophrenia: State of the Art and Next Steps.
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DOI：
10.1176/appi.ajp.2020.20070968
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Ferrarelli F
中科院分区：
文献类型：
--
作者：
Ferrarelli F
睡眠障碍在精神分裂症（SCZ）中常见，包括慢性、早期和首次发作的个体。这已经产生了相当大的兴趣，无论是在临床和研究工作中，在表征睡眠障碍和SCZ之间的关系。睡眠特征可以通过EEG记录进行客观评估。传统上，EEG研究集中在睡眠结构，包括非快速眼动（NREM）和REM睡眠阶段。最近，许多研究调查了睡眠特异性节律的改变，包括与对照组相比，SCZ患者的EEG振荡（如睡眠纺锤波和慢波）。在这篇文章中，我将首先回顾SCZ睡眠障碍的最新证据，从睡眠障碍和这些患者的临床症状之间的关系开始。然后，我将提出研究，证明SCZ和相关精神障碍的睡眠结构和睡眠振荡节律的异常，重点是最近的工作，证明睡眠纺锤波和慢波缺陷的早期课程和首次发作的个人。接下来，我将展示这些睡眠异常如何与SCZ患者的认知障碍相关，并指出潜在的丘脑-皮质回路、Ca+通道活动和GABA/谷氨酸神经传递功能障碍。最后，我将讨论进一步确定睡眠改变在SCZ中的作用所需的一些后续步骤，包括需要调查精神病谱系中的睡眠异常，并确定其与昼夜节律紊乱的关系，这反过来将有助于开发新的睡眠知情治疗干预措施。
Sleep disturbances are commonly observed in schizophrenia (SCZ), including chronic, early course, and first episode individuals. This has generated considerable interest, both in the clinical and research endeavors, in characterizing the relationship between disturbed sleep and SCZ. Sleep features can be objectively assessed with EEG recordings. Traditionally, EEG studies have focused on sleep architecture, which includes non-rapid eye movement (NREM) and REM sleep stages. More recently, numerous studies have investigated alterations in sleep-specific rhythms, including EEG oscillations like sleep spindles and slow waves of individuals with SCZ relative to control groups. In this article, I will first review the state-of-the-art evidence of disturbed sleep in SCZ, starting from the relationship between sleep disturbances and the clinical symptoms of these patients. I will then present studies demonstrating abnormalities in sleep architecture and sleep oscillatory rhythms in SCZ and related psychotic disorders with an emphasis on recent work demonstrating sleep spindles and slow wave deficits in early course and first-episode individuals. Next, I will show how these sleep abnormalities relate to the cognitive impairments in patients diagnosed with SCZ and point to dysfunctions in underlying thalamo-cortical circuits, Ca+ channel activity, and GABA/glutamate neurotransmission. Finally, I will discuss some of the next steps needed to further establish the role of altered sleep in SCZ, including the need to investigate sleep abnormalities across the psychotic spectrum and establishing their relationship with circadian disturbances, which in turn will contribute to the development of novel, sleep informed treatment interventions.
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影响因子：
5.7
作者：
Buchmann A;Dentico D;Peterson MJ;Riedner BA;Sarasso S;Massimini M;Tononi G;Ferrarelli F
通讯作者：
Ferrarelli F
影响因子：
3.2
作者：
Chong HY;Teoh SL;Wu DB;Kotirum S;Chiou CF;Chaiyakunapruk N
通讯作者：
Chaiyakunapruk N
影响因子：
4.5
作者：
Baran B;Correll D;Vuper TC;Morgan A;Durrant SJ;Manoach DS;Stickgold R
通讯作者：
Stickgold R
影响因子：
3.4
作者：
Castelnovo, Anna;Graziano, Bianca;D'Agostino, Armando
通讯作者：
D'Agostino, Armando
影响因子：
10.5
作者：
Chen, Yu-Han;Stone-Howell, Breannan;Caniye, Jose M.
通讯作者：
Caniye, Jose M.