In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion-preparation approach.
In vivo diffusion-tensor MRI of the human heart on a 3 tesla clinical scanner: An optimized second order (M2) motion compensated diffusion-preparation approach.
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DOI：
10.1002/mrm.26380
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发表时间：
2016-11
影响因子：
3.3
通讯作者：
Li, Debiao
中科院分区：
文献类型：
--
作者：
Nguyen, Christopher;Fan, Zhaoyang;Xie, Yibin;Pang, Jianing;Speier, Peter;Bi, Xiaoming;Kobashigawa, Jon;Li, Debiao
关键词：
本研究的目的是优化扩散准备平衡稳态自由旋进心脏MRI（CMR）技术，以在3 T临床扫描仪上对人体进行扩散张量CMR（DT-CMR）。先前开发的二阶运动补偿（M2）扩散准备方案显著缩短（40%），为DT-CMR成像提供了足够的SNR。在20名健康志愿者和3名心力衰竭（HF）患者中，进行了DT-CMR，比较了无运动补偿（M0）、一阶运动补偿（M1）和优化的M2。计算平均扩散率（MD）、各向异性分数（FA）、螺旋角（HA）和HA透壁斜率（HATS）。研究了再现性和成功率（SR）。M2衍生的左心室（LV）MD、FA和HATS（1.4±0.2 um 2/ms，0.28±0.06，−1.0±0.2°/% transs）显著（p<0.001）小于M1（1.8±0.3 um 2/ms，0.46±0.14，−0.1±0.3°/% transs）和M0（4.8±1.0 um 2/ms，0.70±0.14，0.1±0.3°/% transs），表明运动损坏较少，产生的值与以前的文献更一致。M2获得的DT-CMR参数的可重复性（ICC>0.85）和SR（82%）高于M1（ICC=0.20-0.85，SR=37%）和M0（ICC=0.20-0.30，SR=11%）。M2 DT-CMR能够生成HA标测图，从心内膜到心外膜具有平滑的透壁过渡。在3 T临床扫描仪上，申报的M2 DT-CMR可重复产生平均LV MD、FA、HA和HATS的整体运动稳健估计。
The aim of this study was to optimize a diffusion-prepared balanced steady-state free precession cardiac MRI (CMR) technique to perform diffusion-tensor CMR (DT-CMR) in humans on a 3T clinical scanner. A previously developed second order motion compensated (M2) diffusion-preparation scheme was significantly shortened (40%) yielding sufficient SNR for DT-CMR imaging. In 20 healthy volunteers and 3 heart failure (HF) patients, DT-CMR was performed comparing no motion compensation (M0), first order motion compensation (M1), and the optimized M2. Mean diffusivity (MD), fractional anisotropy (FA), helix angle (HA), and HA transmural slope (HATS) were calculated. Reproducibility and success rate (SR) were investigated. M2-derived left ventricular (LV) MD, FA, and HATS (1.4±0.2 um2/ms, 0.28±0.06, −1.0±0.2°/%trans) were significantly (p<0.001) less than M1 (1.8±0.3 um2/ms, 0.46±0.14, −0.1±0.3°/%trans) and M0 (4.8±1.0 um2/ms, 0.70±0.14, 0.1±0.3°/%trans) indicating less motion corruption and yielding values more consistent with previous literature. M2-derived DT-CMR parameters had higher reproducible (ICC>0.85) and SR (82%) than M1 (ICC=0.20-0.85, SR=37%) and M0 (ICC=0.20-0.30, SR=11%). M2 DT-CMR was able to yield HA maps with smooth transmural transition from endocardium to epicardium. The proposed M2 DT-CMR reproducibly yielded bulk motion robust estimations of mean LV MD, FA, HA, and HATS on a 3T clinical scanner.
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影响因子：
3.3
作者：
Lin, Alexander P.;Bennett, Eric;Wisk, Lauren E.;Gharib, Morteza;Fraser, Scott E.;Wen, Han
通讯作者：
Wen, Han
DOI：
10.1186/1532-429x-14-70
发表时间：
2012-10-12
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Mekkaoui C;Huang S;Chen HH;Dai G;Reese TG;Kostis WJ;Thiagalingam A;Maurovich-Horvat P;Ruskin JN;Hoffmann U;Jackowski MP;Sosnovik DE
通讯作者：
Sosnovik DE
影响因子：
3.3
作者：
Jenista ER;Rehwald WG;Chen EL;Kim HW;Klem I;Parker MA;Kim RJ
通讯作者：
Kim RJ
影响因子：
3.3
作者：
Beg, MF;Helm, PA;Winslow, RL
通讯作者：
Winslow, RL
影响因子：
3.7
作者：
Mekkaoui C;Porayette P;Jackowski MP;Kostis WJ;Dai G;Sanders S;Sosnovik DE
通讯作者：
Sosnovik DE