Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition.
Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition.
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儿童的全氟化学（PFC）暴露：与反应抑制受损的关联。
DOI：
10.1021/es103712g
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发表时间：
2011-10-01
影响因子：
11.4
通讯作者：
Kannan, Kurunthachalam
中科院分区：
文献类型：
--
作者：
Gump, Brooks B.;Wu, Qian;Dumas, Amy K.;Kannan, Kurunthachalam
自20世纪50年代以来，全氟化学品（PFCs）已被广泛用于消费品中，目前在地球仪的人类和动物血液中发现了可检测水平。与这种广泛接触全氟化碳的情况形成鲜明对比的是，关于接触这些化学品对健康的潜在不利影响的研究相对较少。我们进行了这项横断面研究，以确定特定的血液PFC水平是否与儿童反应抑制受损有关。在儿童（N = 83）中测量了11种PFC的血液水平，其中6种PFC：全氟辛烷磺酸（PFOS），全氟己烷硫酸盐（PFHxS），全氟辛酸（PFOA），全氟壬酸（PFNA），全氟辛烷磺酰胺（PFOSA）和全氟癸酸（PFDA）-在大多数儿童中发现可检测水平（87.5%或更高）。这些水平进行了分析有关的差异强化低反应率（DRL）的任务。该任务奖励响应之间的延迟（即，更长的反应间时间; IRT），因此构成反应抑制的量度。在DRL任务期间，血液中PFOS、PFNA、PFDA、PFHxS和PFOSA水平较高与IRT显著缩短相关。这些协会的幅度是这样的，IRT在任务期间下降了29-34%，每1 SD增加相应的血液PFC。这项研究表明PFC暴露和儿童的冲动之间的关联。虽然有趣，有必要进一步调查和复制更大的儿童样本。
Perfluorinated chemicals (PFCs) have been used widely in consumer products since the 1950s and are currently found at detectable levels in the blood of humans and animals across the globe. In stark contrast to this widespread exposure to PFCs, there is relatively little research on potential adverse health effects of exposure to these chemicals. We performed this cross-sectional study to determine if specific blood PFC levels are associated with impaired response inhibition in children. Blood levels of 11 PFCs were measured in children (N = 83) and 6 PFCs: perfluorooctane sulfonate (PFOS), perfluorohexane sulfate (PFHxS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorooctanesulfonamide (PFOSA), and perfluorodecanoic acid (PFDA) – were found at detectable levels in most children (87.5% or greater had detectable levels). These levels were analyzed in relation to the differential reinforcement of low rates of responding (DRL) task. This task rewards delays between responses (i.e., longer inter-response times; IRTs) and therefore constitutes a measure of response inhibition. Higher levels of blood PFOS, PFNA, PFDA, PFHxS, and PFOSA were associated with significantly shorter IRTs during the DRL task. The magnitude of these associations was such that IRTs during the task decreased by 29–34% for every 1 SD increase in the corresponding blood PFC. This study suggests an association between PFC exposure and children’s impulsivity. Although intriguing, there is a need for further investigation and replication with a larger sample of children.
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影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
5
作者：
Fei, Chunyuan;McLaughlin, Joseph K.;Olsen, Jorn
通讯作者：
Olsen, Jorn
影响因子：
4.5
作者：
Bogdanska, Jasna;Borg, Daniel;Nobel, Stefan
通讯作者：
Nobel, Stefan
影响因子：
10.4
作者：
Fei C;McLaughlin JK;Lipworth L;Olsen J
通讯作者：
Olsen J
影响因子：
3.3
作者：
Butenhoff, John L.;Chang, Shu-Ching;York, Raymond G.
通讯作者：
York, Raymond G.