Vaginal Nanoformulations for the Management of Preterm Birth.
Vaginal Nanoformulations for the Management of Preterm Birth.
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DOI：
10.3390/pharmaceutics14102019
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发表时间：
2022-09-23
期刊：
影响因子：
5.4
通讯作者：
Reznik, Sandra E.
中科院分区：
文献类型：
--
作者：
Mir, Asad;Vartak, Richa V.;Patel, Ketan;Yellon, Steven M.;Reznik, Sandra E.
关键词：
早产是世界上婴儿发病率和死亡率的主要原因。2020年，美国每10名婴儿中就有1名早产。世界卫生组织估计，每年共有1500万名婴儿早产。目前对肺结核的治疗干预措施取得的可复制成功有限。纳米医学领域的最新进展使利用阴道给药途径有效和局部地将药物输送到女性生殖道成为可能。此外，使用小鼠模型进行的研究提供了关于宫颈作为怀孕和分娩的守门人的重要见解。随着最近的这些发展，生殖生物学领域正处于治疗肺结核的范式转变的尖端。目前的综述集中在与治疗疾病相关的复杂性和在临床前研究中产生了有希望的结果的新的治疗方法。
Preterm birth (PTB) is a leading cause of infant morbidity and mortality in the world. In 2020, 1 in 10 infants were born prematurely in the United States. The World Health Organization estimates that a total of 15 million infants are born prematurely every year. Current therapeutic interventions for PTB have had limited replicable success. Recent advancements in the field of nanomedicine have made it possible to utilize the vaginal administration route to effectively and locally deliver drugs to the female reproductive tract. Additionally, studies using murine models have provided important insights about the cervix as a gatekeeper for pregnancy and parturition. With these recent developments, the field of reproductive biology is on the cusp of a paradigm shift in the context of treating PTB. The present review focuses on the complexities associated with treating the condition and novel therapeutics that have produced promising results in preclinical studies.
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