H9N2 influenza virus in China: a cause of concern.

H9N2 influenza virus in China: a cause of concern.
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中国的 H9N2 流感病毒:令人担忧

DOI:
10.1007/s13238-014-0111-7
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发表时间:
2015-01
期刊:
影响因子:
21.1
通讯作者:
Liu, Jinhua
Liu, Jinhua
中科院分区:
生物学1区
文献类型:
--
作者:
Sun, Yipeng;Liu, Jinhua

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最近人类感染禽流感病毒的事件显示,H9 N2流感病毒是感染人类的H7N9和H10 N8病毒的基因供体。H9 N2病毒在动物-人类界面中的关键作用可能是由于广泛的宿主范围,家禽和哺乳动物的适应性以及广泛的基因重排。H9 N2是我国鸡群中流行最广的流感病毒亚型,即使在长期的疫苗接种计划下,也会给养禽业造成巨大的经济损失。本文就H9 N2亚型流感病毒的历史、流行病学、生物学特性及分子决定因素等方面进行综述。H9 N2基因,特别是RNP基因在人类感染中的作用有待于进一步研究。
The recent human infection with avian influenza virus revealed that H9N2 influenza virus is the gene donor for H7N9 and H10N8 viruses infecting humans. The crucial role of H9N2 viruses at the animal-human interface might be due to the wide host range, adaptation in both poultry and mammalian, and extensive gene reassortment. As the most prevalent subtype of influenza viruses in chickens in China, H9N2 also causes a great economic loss for the poultry industry, even under the long-term vaccination programs. The history, epidemiology, biological characteristics, and molecular determinants of H9N2 influenza virus are reviewed in this paper. The contribution of H9N2 genes, especially RNP genes, to the infection of humans needs to be investigated in the future.
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