Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer.
Prognostic value of alcohol dehydrogenase mRNA expression in gastric cancer.
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DOI：
10.3892/ol.2018.8007
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发表时间：
2018-04
期刊：
影响因子：
2.9
通讯作者：
Zeng X
中科院分区：
文献类型：
--
作者：
Guo E;Wei H;Liao X;Xu Y;Li S;Zeng X
以往的研究表明乙醇脱氢酶（ADH）同工酶对胃癌具有诊断价值。然而，ADH同工酶在胃癌中的预后价值仍不清楚。本研究的目的是确定ADH基因在胃癌患者中的预后价值。使用Kaplan-Meier工具研究ADH基因在GC患者中的预后价值。Kaplan-Meier曲线用于评估具有不同疾病的GC患者组之间的差异。风险比（HR）和95%置信区间（CI）用于评估GC生存的相对风险。总的来说，593例携带GC和7个ADH基因的患者被纳入生存分析。ADH 1A（1类），α多肽的高表达（ADH 1A;对数秩P=0.043; HR=0.79; 95% CI：0.64-0.99）、ADH 1B（1类）、β多肽（ADH 1B;对数秩P=1.9×10−05; HR=0.65; 95% CI：0.53-0.79）和ADH 5（III类）、χ多肽（ADH 5;对数秩P=0.0011; HR=0.73; 95%CI：0.6-0.88）导致与那些基因低表达的患者相比，所有GC患者的死亡风险显著降低。此外，在ADH 1B高表达的胃肠道型胃癌患者中可能还观察到保护作用（对数秩P=0.031; HR=0.64; 95% CI：0.43-0.96）和ADH 1A高表达的弥漫型胃癌患者（对数秩P=0.014; HR=0.51; 95% CI：0.3-0.88），ADH 1B（对数秩P=0.04; HR=0.53; 95% CI：0.29-0.98），ADH 4（II类），π多肽（对数秩P=0.033; HR=0.58; 95% CI：0.35-0.96）和ADH 6（V类）（对数秩P=0.037; HR=0.59; 95%CI：0.35-0.97），导致与这些基因低表达的患者相比，死亡风险显著降低。相反，弥漫型胃癌患者ADH 5高表达（对数秩P=0.044; HR=1.66; 95%CI：1.01-2.74）与预后不良显著相关。本研究的结果表明，ADH 1A和ADH 1B可能是胃癌的潜在预后生物标志物，而其他ADH基因的预后价值需要进一步研究。
Previous studies have reported that alcohol dehydrogenase (ADH) isoenzymes possess diagnostic value in gastric cancer (GC). However, the prognostic value of ADH isoenzymes in GC remains unclear. The aim of the present study was to identify the prognostic value of ADH genes in patients with GC. The prognostic value of ADH genes was investigated in patients with GC using the Kaplan-Meier plotter tool. Kaplan-Meier plots were used to assess the difference between groups of patients with GC with different prognoses. Hazard ratios (HR) and 95% confidence intervals (CI) were used to assess the relative risk of GC survival. Overall, 593 patients with GC and 7 ADH genes were included in the survival analysis. High expression of ADH 1A (class 1), α polypeptide (ADH1A; log-rank P=0.043; HR=0.79; 95% CI: 0.64–0.99), ADH 1B (class 1), β polypeptide (ADH1B; log-rank P=1.9×10−05; HR=0.65; 95% CI: 0.53–0.79) and ADH 5 (class III), χ polypeptide (ADH5; log-rank P=0.0011; HR=0.73; 95% CI: 0.6–0.88) resulted in a significantly decreased risk of mortality in all patients with GC compared with patients with low expression of those genes. Furthermore, protective effects may additionally be observed in patients with intestinal-type GC with high expression of ADH1B (log-rank P=0.031; HR=0.64; 95% CI: 0.43–0.96) and patients with diffuse-type GC with high expression of ADH1A (log-rank P=0.014; HR=0.51; 95% CI: 0.3–0.88), ADH1B (log-rank P=0.04; HR=0.53; 95% CI: 0.29–0.98), ADH 4 (class II), π polypeptide (log-rank P=0.033; HR=0.58; 95% CI: 0.35–0.96) and ADH 6 (class V) (log-rank P=0.037; HR=0.59; 95% CI: 0.35–0.97) resulting in a significantly decreased risk of mortality compared with patients with low expression of those genes. In contrast, patients with diffuse-type GC with high expression of ADH5 (log-rank P=0.044; HR=1.66; 95% CI: 1.01–2.74) were significantly correlated with a poor prognosis. The results of the present study suggest that ADH1A and ADH1B may be potential prognostic biomarkers of GC, whereas the prognostic value of other ADH genes requires further investigation.
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影响因子：
30.8
作者：
Hashibe, Mia;Mckay, James D.;Brennan, Paul
通讯作者：
Brennan, Paul
影响因子：
3.1
作者：
Jelski, W;Zalewski, B;Szmitkowski, M
通讯作者：
Szmitkowski, M
影响因子：
4.4
作者：
Jelski, Wojciech;Laniewska-Dunaj, Magdalena;Orywal, Karolina;Kochanowicz, Jan;Rutkowski, Robert;Szmitkowski, Maciej
通讯作者：
Szmitkowski, Maciej
影响因子：
4.6
作者：
Jelski, Wojciech;Orywal, Karolina;Szmitkowski, Maciej
通讯作者：
Szmitkowski, Maciej
影响因子：
3.1
作者：
Jelski, Wojciech;Kozlowski, Miroslaw;Szmitkowski, Maciej
通讯作者：
Szmitkowski, Maciej