Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health
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中药多糖靶向肠道菌群促进健康的分子机制

DOI:
10.1007/s11655-022-3522-y
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发表时间:
2022-05
影响因子:
2.9
通讯作者:
Shi-Jun Wang
Shi-Jun Wang
中科院分区:
医学3区
文献类型:
--
作者:
Wen-Xiao Zhao;Tong Wang;Ya-Nan Zhang;Qian Chen;Yuan Wang;Yan-Qing Xing;Jun Zheng;Chen-Chen Duan;Li-Jun Chen;Hai-Jun Zhao;Shi-Jun Wang

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越来越多的证据表明,肠道微生物群在包括肥胖、2型糖尿病、心力衰竭和非酒精性脂肪性肝病等疾病的病理过程中起着重要作用。从中药中提取的多糖不仅可以缓解病理状态,还可以通过抗炎、调节免疫、降低血糖和血脂、抗癌和抗氧化来促进健康。肠道微生物群组成和代谢途径的改变是中药多糖治疗的潜在机制。此外,它们通过肠 - 器官轴发挥作用,或者通过与肠道微生物群介导的其他药物或成分协同作用发挥间接作用。这篇综述总结了中药多糖作为潜在益生元与肠道微生物相互作用促进健康的分子机制。
The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity, type 2 diabetes mellitus, heart failure, and non-alcoholic fatty liver disease. Polysaccharides extracted from Chinese medicine (CM) can not only alleviate pathological status but also promote health by anti-inflammatory, regulating immunity, lowering blood glucose and lipids, anti-cancer, and anti-oxidation. The alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides treatment. In addition, they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut microbiota. This review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics for promoting health.
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