Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety.
Neurochemical pathways that converge on thalamic trigeminovascular neurons: potential substrate for modulation of migraine by sleep, food intake, stress and anxiety.
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DOI：
10.1371/journal.pone.0103929
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Burstein R
中科院分区：
文献类型：
--
作者：
Noseda R;Kainz V;Borsook D;Burstein R
感觉信号的动态丘脑调节允许皮层更好地适应快速变化的行为，生理和环境需求。为了实现这一作用，丘脑神经元本身必须受到不断变化的调节输入，这些输入起源于涉及自主神经、情感和认知功能的多个神经化学通路。我们的总体目标是定义一个解剖学框架，概念化如何“决定”是否三叉神经血管丘脑神经元火灾，多久，在什么频率。为了开始回答这个问题，我们确定哪些神经肽/神经递质能够调节丘脑三叉神经血管神经元。结合在体单细胞记录、四甲基罗丹明葡聚糖（TMR）细胞外标记和离体免疫组织化学方法，我们发现丘脑三叉神经血管神经元周围有高密度的含有谷氨酸、GABA、多巴胺和5-羟色胺生物标志物的轴突，中等密度的含有去甲肾上腺素和组胺的轴突，低密度的含有食欲素和黑色素浓集激素（MCH）的轴突，高密度的含有多巴胺和5-羟色胺生物标志物的轴突。但不包括含有CGRP、5-羟色胺1D受体、催产素或加压素的轴突。在偏头痛的背景下，研究结果表明，头痛相关的伤害性信号从丘脑到皮质的传递可能受到相反的力（即，易化性、抑制性），由保持生理、行为、认知和情绪稳态所需的持续调整所支配。
Dynamic thalamic regulation of sensory signals allows the cortex to adjust better to rapidly changing behavioral, physiological and environmental demands. To fulfill this role, thalamic neurons must themselves be subjected to constantly changing modulatory inputs that originate in multiple neurochemical pathways involved in autonomic, affective and cognitive functions. Our overall goal is to define an anatomical framework for conceptualizing how a ‘decision’ is made on whether a trigeminovascular thalamic neuron fires, for how long, and at what frequency. To begin answering this question, we determine which neuropeptides/neurotransmitters are in a position to modulate thalamic trigeminovascular neurons. Using a combination of in-vivo single-unit recording, juxtacellular labeling with tetramethylrhodamine dextran (TMR) and in-vitro immunohistochemistry, we found that thalamic trigeminovascular neurons were surrounded by high density of axons containing biomarkers of glutamate, GABA, dopamine and serotonin; moderate density of axons containing noradrenaline and histamine; low density of axons containing orexin and melanin concentrating hormone (MCH); but not axons containing CGRP, serotonin 1D receptor, oxytocin or vasopressin. In the context of migraine, the findings suggest that the transmission of headache-related nociceptive signals from the thalamus to the cortex may be modulated by opposing forces (i.e., facilitatory, inhibitory) that are governed by continuous adjustments needed to keep physiological, behavioral, cognitive and emotional homeostasis.
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影响因子：
56.9
作者：
Fremeau, RT;Kam, K;Edwards, RH
通讯作者：
Edwards, RH
影响因子：
2.8
作者：
Barroso-Chinea, Pedro;Castle, Maria;Lanciego, Jose L.
通讯作者：
Lanciego, Jose L.
影响因子：
3.3
作者：
EATON, SA;SALT, TE
通讯作者：
SALT, TE
影响因子：
5.3
作者：
Burdakov, D;Gerasimenko, O;Verkhratsky, A
通讯作者：
Verkhratsky, A
DOI：
10.1073/pnas.96.2.748
发表时间：
1999-01-19
影响因子：
11.1
作者：
Date, Y;Ueta, Y;Nakazato, M
通讯作者：
Nakazato, M