Triglycerides to High-Density Lipoprotein Cholesterol Ratio Is the Best Surrogate Marker for Insulin Resistance in Nonobese Middle-Aged and Elderly Population: A Cross-Sectional Study.
Triglycerides to High-Density Lipoprotein Cholesterol Ratio Is the Best Surrogate Marker for Insulin Resistance in Nonobese Middle-Aged and Elderly Population: A Cross-Sectional Study.
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甘油三酯与高密度脂蛋白胆固醇的比率是非肥胖中老年人群胰岛素抵抗的最佳替代标志物：一项横断面研究
DOI：
10.1155/2021/6676569
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发表时间：
2021
影响因子：
2.8
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Yang Y;Wang B;Yuan H;Li X
目的 胰岛素抵抗 (IR) 与代谢特征密切相关，包括肥胖和血脂异常。本研究的目的是探讨中国非肥胖中老年人群的血脂状况与 IR 之间的关系。方法 这项横断面研究包括 1608 名受试者。 IR 的定义是胰岛素抵抗稳态模型评估 (HOMA-IR) 至少为 2.5。结果 在非肥胖受试者中（体重指数 (BMI) < 25 kg/m2，n = 996），甘油三酯 (TG) 与高密度脂蛋白胆固醇 (HDL-C) 之比（比值比 (OR) = 1.43，95% 置信区间 (CI) 1.13–1.81，P=0.003）是独立的IR 的危险因素。预测非肥胖受试者 IR 的最佳标志物是 TG/HDL-C 比值，受试者工作特征曲线下面积 (AUC) 为 0.73 (P < 0.001)。在非肥胖人群中，确定 TG/HDL-C 比率 IR 的最佳临界点是 ≥1.50。其他标志物，如 BMI、TG 和总胆固醇 (TC)/HDL-C，对于预测非肥胖人群的 IR 也具有可接受的区分力（AUC ≥ 0.7 且 P < 0.001）。调整后BMI的AUC最高为0.647（P < 0.001），但对于肥胖受试者的IR预测效果不够（BMI ≥ 25.0，n = 612）。结论 TG/HDL-C比值可能是预测中国非肥胖中老年人群IR的最可靠指标。
Objective Insulin resistance (IR) is closely associated with metabolic profiles, including obesity and dyslipidemia. The aim of the present study was to examine how lipid profiles were associated with IR in nonobese middle-aged and elderly Chinese population. Methods This cross-sectional study included 1608 subjects. IR was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. Results In nonobese subjects (body mass index (BMI) < 25 kg/m2, n = 996), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (odds ratio (OR) = 1.43, 95% confidence interval (CI) 1.13–1.81, P=0.003) was an independent risk factor for IR. The best marker for predicting IR in nonobese subjects was TG/HDL-C ratio with the areas under the receiver operating characteristic curves (AUC) of 0.73 (P < 0.001). The optimal cut-off point to identifying IR for TG/HDL-C ratio was ≥1.50 in the nonobese population. Other markers like BMI, TG, and total cholesterol (TC)/HDL-C also had acceptable discriminatory power for predicting IR in nonobese population (AUC ≥ 0.7 and P < 0.001). BMI had the highest AUC of 0.647 (P < 0.001) after being adjusted, but it was not effective enough to predict IR in obese subjects (BMI ≥ 25.0, n = 612). Conclusions The TG/HDL-C ratio may be the best reliable marker for predicting IR in the nonobese middle-aged and elderly Chinese population.
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DOI：
10.26355/eurrev_202010_23426
发表时间：
2020-01-01
影响因子：
3.3
作者：
Klisic, A.;Kavaric, N.;Ninic, A.
通讯作者：
Ninic, A.
影响因子：
5.1
作者：
Puavilai, G;Chanprasertyotin, S;Sriphrapradaeng, A
通讯作者：
Sriphrapradaeng, A
影响因子：
1.4
作者：
Locateli, Joao Carlos;Lopes, Wendell Arthur;Nardo Junior, Nelson
通讯作者：
Nardo Junior, Nelson
影响因子：
9.3
作者：
Li, Chaoyang;Ford, Earl S.;Reaven, Gerald M.
通讯作者：
Reaven, Gerald M.
影响因子：
16.2
作者：
Elahl, D
通讯作者：
Elahl, D