Metabolic hormones in saliva: origins and functions.
Metabolic hormones in saliva: origins and functions.
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DOI：
10.1111/odi.12015
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发表时间：
2013-04
期刊：
影响因子：
3.8
通讯作者：
Zolotukhin S
中科院分区：
文献类型：
--
作者：
Zolotukhin S
唾液蛋白质组由数千种蛋白质组成，其中包括能量摄入和输出的荷尔蒙调节器等。尽管这种重要的激素在全身能量代谢中的功能已有很好的描述，但它们在口腔中的功能，无论是作为唾液成分，还是在味觉细胞中表达，都很少被研究和了解。大多数唾液代谢激素的相应受体也被证明在唾液腺、味觉细胞或口腔粘膜的其他细胞中表达。本文综述了在唾液、唾液腺或舌上皮中发现的胃肠激素、脂肪因子和神经肽，以及它们在口腔中表达的同源受体。令人惊讶的是，很少有功能被分配给唾液代谢激素，而这些功能大多与味觉的调节有关。由于口腔营养感觉受损与能量摄入量和体重指数增加之间的相关性已得到很好的描述，因此引入了一种概念性的挑衅性观点，认为唾液成分的有针对性的变化可能会影响全身的代谢，以响应口腔粘膜局部表达的同源受体的激活。
The salivary proteome consists of thousands of proteins, which include, among others, hormonal modulators of energy intake and output. Although the functions of this prominent category of hormones in whole body energy metabolism are well characterized, their functions in the oral cavity, whether as a salivary component, or when expressed in taste cells, are less studied and poorly understood. The respective receptors for the majority of salivary metabolic hormones have been also shown to be expressed in salivary glands, taste cells, or other cells in the oral mucosa. This review provides a comprehensive account of the gastrointestinal hormones, adipokines, and neuropeptides identified in saliva, salivary glands, or lingual epithelium, as well as their respective cognate receptors expressed in the oral cavity. Surprisingly, few functions are assigned to salivary metabolic hormones, and these functions are mostly associated with the modulation of taste perception. Because of the well-characterized correlation between impaired oral nutrient sensing and increased energy intake and body mass index, a conceptually provocative point of view is introduced, whereupon it is argued that targeted changes in the composition of saliva could affect whole body metabolism in response to the activation of cognate receptors expressed locally in the oral mucosa.
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