The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.

The Locus Coeruleus- Norepinephrine System in Stress and Arousal: Unraveling Historical, Current, and Future Perspectives.
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DOI:
10.3389/fpsyt.2020.601519
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发表时间:
2020
影响因子:
4.7
通讯作者:
Van Bockstaele EJ
Van Bockstaele EJ
中科院分区:
医学3区
文献类型:
--
作者:
Ross JA;Van Bockstaele EJ

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唤醒可以理解为一个频谱,一边是过度嗜睡,认知功能障碍和注意力不集中,中间是清醒状态,另一边是过度警觉,恐慌和精神病。然而,从历史上看,唤醒和压力的概念一直难以定义为可测量的实验变量。不同的努力来研究这些主题已经产生了几个学科,包括神经生物学,神经内分泌学和认知神经科学。我们讨论的技术进步,按时间顺序导致我们目前的觉醒系统的理解,专注于多方面的蓝斑核。我们分享我们的当代观点和其他人的假设,在我们目前的技术能力和未来的发展,将需要在这一研究领域向前迈进的背景下。
Arousal may be understood on a spectrum, with excessive sleepiness, cognitive dysfunction, and inattention on one side, a wakeful state in the middle, and hypervigilance, panic, and psychosis on the other side. However, historically, the concepts of arousal and stress have been challenging to define as measurable experimental variables. Divergent efforts to study these subjects have given rise to several disciplines, including neurobiology, neuroendocrinology, and cognitive neuroscience. We discuss technological advancements that chronologically led to our current understanding of the arousal system, focusing on the multifaceted nucleus locus coeruleus. We share our contemporary perspective and the hypotheses of others in the context of our current technological capabilities and future developments that will be required to move forward in this area of research.
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