Decarboxylative Alkynylation.
Decarboxylative Alkynylation.
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DOI：
10.1002/anie.201705107
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发表时间：
2017-09-18
期刊：
影响因子：
--
通讯作者：
Baran PS
中科院分区：
文献类型：
--
作者：
Smith JM;Qin T;Merchant RR;Edwards JT;Malins LR;Liu Z;Che G;Shen Z;Shaw SA;Eastgate MD;Baran PS
采用镍基和铁基催化剂，开发了一种新的脱羧交叉偶联方案，从各种羧酸中获得末端和取代炔。n -羟基四氯眼酰亚胺（TCNHPI）酯的使用对转化的成功至关重要，并且该反应易于原位羧酸活化。此外，一种廉价的、商业上可获得的炔源在这个正式的认证过程中被采用，作为其他成熟的炔合成的替代品。该反应可以在摩尔尺度上进行，条件温和，操作简单，范围广泛，同时为先前报道的合成中间体提供了简洁的途径。各种炔烃：研究了一种简便的氧化还原活性酯脱羧炔烃化反应方法。反应范围广，官能团耐受性强，并且可以通过Ni或Fe催化得到末端和取代的炔。该方法用于快速合成各种炔基中间体，这些中间体以前难以使用传统的炔基化策略获得。
The development of a new decarboxylative cross-coupling protocol that affords terminal and substituted alkynes from various carboxylic acids is described using both nickel- and iron-based catalysts. The use of N-hydroxytetrachlorophthalimide (TCNHPI) esters is crucial to the success of the transformation, and the reaction is amenable to in situ carboxylic acid activation. Additionally, an inexpensive, commercially-available alkyne source is employed in this formal homologation process that serves as a surrogate for other well-established alkyne syntheses. The reaction can be conducted on a mole scale, and the conditions are mild, operationally simple, and broad in scope while providing succinct avenues to previously reported synthetic intermediates. All kinds of Alkynes: A convenient method for the decarboxylative alkynylation of redox active esters has been developed. The reaction is broad, functional group tolerant, and provides access to alkynes that are both terminal and substituted using either Ni or Fe catalysis. The method is used to swiftly synthesize a variety of alkynyl intermediates that were previously difficult to access using conventional alkynylation strategies.
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影响因子：
15
作者：
Himo, F;Lovell, T;Fokin, VV
通讯作者：
Fokin, VV
影响因子：
15
作者：
Candish, Lisa;Teders, Michael;Glorius, Frank
通讯作者：
Glorius, Frank
影响因子：
3.6
作者：
Bi, Hai-Peng;Teng, Qingfeng;Li, Chao-Jun
通讯作者：
Li, Chao-Jun
影响因子：
2.1
作者：
Einhorn, C;Einhorn, J;Marcadal-Abbadi, C
通讯作者：
Marcadal-Abbadi, C
影响因子：
5.2
作者：
Cheung, Chi Wai;Ren, Peng;Hu, Xile
通讯作者：
Hu, Xile