Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.
Convergent neural correlates of prenatal exposure to air pollution and behavioral phenotypes of risk for internalizing and externalizing problems: Potential biological and cognitive pathways.
复制标题
DOI：
10.1016/j.neubiorev.2022.104645
复制
发表时间：
2022-06
影响因子：
8.2
通讯作者：
Champagne, Frances A.
中科院分区：
文献类型：
--
作者：
Margolis, Amy E.;Liu, Ran;Conceicao, Vasco A.;Ramphal, Bruce;Pagliaccio, David;DeSerisy, Mariah L.;Koe, Emily;Selmanovic, Ena;Raudales, Amarelis;Emanet, Nur;Quinn, Aurabelle E.;Beebe, Beatrice;Pearson, Brandon L.;Herbstman, Julie B.;Rauh, Virginia A.;Fifer, William P.;Fox, Nathan A.;Champagne, Frances A.
人类普遍暴露于空气污染中的神经毒物，导致精神疾病风险增加。产前暴露于空气污染对早期出现的行为表型的影响，增加了精神病理学的风险仍然研究不足。我们回顾了代表人类行为表型类似物的动物模型，这些表型是内化和外化问题（行为抑制，行为丰富，易怒）的风险标志，并确定这些行为表型背后的神经机制和三种类型的空气污染物（多环芳烃，交通相关的空气污染物，< 2.5微米的细颗粒物）的神经靶点之间的共性。我们的结论是，产前暴露于空气污染物通过不同的机制，包括改变多巴胺能信号和海马形态，神经炎症，减少脑源性神经营养因子的表达，增加行为抑制和易怒的风险。未来的研究应该在人类纵向研究中调查这些影响，包括复杂的暴露测量方法，神经成像，气质表型和神经认知处理的行为表征，以促进旨在改善儿童长期发展益处的努力，特别是那些生活在高水平暴露地区的儿童。
Humans are ubiquitously exposed to neurotoxicants in air pollution, causing increased risk for psychiatric outcomes. Effects of prenatal exposure to air pollution on early emerging behavioral phenotypes that increase risk of psychopathology remain understudied. We review animal models that represent analogues of human behavioral phenotypes that are risk markers for internalizing and externalizing problems (behavioral inhibition, behavioral exuberance, irritability), and identify commonalities among the neural mechanisms underlying these behavioral phenotypes and the neural targets of three types of air pollutants (polycyclic aromatic hydrocarbons, traffic-related air pollutants, fine particulate matter < 2.5 microns). We conclude that prenatal exposure to air pollutants increases risk for behavioral inhibition and irritability through distinct mechanisms, including altered dopaminergic signaling and hippocampal morphology, neuroinflammation, and decreased brain-derived neurotrophic factor expression. Future studies should investigate these effects in human longitudinal studies incorporating complex exposure measurement methods, neuroimaging, and behavioral characterization of temperament phenotypes and neurocognitive processing to facilitate efforts aimed at improving long-lasting developmental benefits for children, particularly those living in areas with high levels of exposure.
登录
查看更多内容
DOI：
10.1111/ejn.15158
发表时间：
2022-05
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Clinton SM;Shupe EA;Glover ME;Unroe KA;McCoy CR;Cohen JL;Kerman IA
通讯作者：
Kerman IA
DOI：
10.1146/annurev-clinpsy-032816-044941
发表时间：
2017-01-01
期刊：
ANNUAL REVIEW OF CLINICAL PSYCHOLOGY, VOL 13
影响因子：
--
作者：
Brotman, Melissa A.;Kircanski, Katharina;Leibenluft, Ellen
通讯作者：
Leibenluft, Ellen
DOI：
10.1016/j.jaac.2017.10.007
发表时间：
2017-12-01
影响因子：
13.3
作者：
Buzzell, George A.;Troller-Renfree, Sonya V.;Fox, Nathan A.
通讯作者：
Fox, Nathan A.
影响因子：
3.5
作者：
Caruso, M. J.;McClintock, M. K.;Cavigelli, S. A.
通讯作者：
Cavigelli, S. A.
影响因子：
10.4
作者：
Chiu YH;Bellinger DC;Coull BA;Anderson S;Barber R;Wright RO;Wright RJ
通讯作者：
Wright RJ