Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats.
Temperament moderates the influence of periadolescent social experience on behavior and adrenocortical activity in adult male rats.
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DOI：
10.1016/j.yhbeh.2014.07.010
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发表时间：
2014-08
影响因子：
3.5
通讯作者：
Cavigelli, S. A.
中科院分区：
文献类型：
--
作者：
Caruso, M. J.;McClintock, M. K.;Cavigelli, S. A.
青春期是行为和生理上显著成熟的时期，特别是与应激反应有关的时期。测试青少年社会经历对压力相关行为和生理发展的影响的动物研究得出了复杂的结果。我们使用了一种新恐惧症的啮齿动物模型来检验青春期社会经历对成人行为和肾上腺皮质功能的影响是由青春期前的气质调节的假设。在出生后28-46天，对53只雄性SD大鼠的探索活动进行了评估，以对它们的气质进行分类，然后将它们安置在三种条件中的一种：(1)有熟悉的亲属，(2)有新的社会伙伴，或(3)单独没有社会伙伴。在PND 110-114期间，当大鼠被单独安置并暴露在1小时的新的社会挑战中时，从收集的粪便样本中评估了对成年肾上腺皮质功能的影响。有新的或没有社会伴侣的青春期住房导致成人糖皮质激素的产生比有熟悉的猫咪的青春期住房减少。此外，与那些在青春期与熟悉或没有社会伙伴的大鼠相比，在青春期与新的社会伙伴一起生活的高探索性早期断奶大鼠表现出更多的探索性行为，成年后更快地恢复到基础糖皮质激素的产生，与接触新社会伙伴的低探索性大鼠相比。总而言之，相对短期的青少年社会经历可能会导致性情的短暂变化，并可能导致糖皮质激素生产恢复的长期变化，以应对成人的社会挑战。此外，早期气质可能会调节青春期经历对成人行为和肾上腺皮质功能的影响。
Adolescence is a period of significant behavioral and physiological maturation, particularly related to stress responses. Animal studies that have tested the influence of adolescent social experiences on stress-related behavioral and physiological development have led to complex results. We used a rodent model of neophobia to test the hypothesis that the influence of adolescent social experience on adult behavior and adrenocortical function is modulated by preadolescent temperament. Exploratory activity was assessed in 53 male Sprague-Dawley rats to classify temperament and then they were housed in one of three conditions during postnatal days (PND) 28-46: (1) with familiar kin, (2) with novel social partners, or (3) individually with no social partners. Effects on adult adrenocortical function were evaluated from fecal samples collected while rats were individually-housed and exposed to a 1-hour novel social challenge during PND 110-114. Adolescent-housing with novel or no social partners led to reduced adult glucocorticoid production compared to adolescent-housing with familiar littermates. Additionally, highly-exploratory pre-weanling rats that were housed with novel social partners during adolescence exhibited increased exploratory behavior and a more rapid return to basal glucocorticoid production in adulthood compared to those housed with familiar or no social partners during adolescence and compared to low-exploratory rats exposed to novel social partners. In sum, relatively short-term adolescent social experiences can cause transient changes in temperament and potentially longer-term changes in recovery of glucocorticoid production in response to adult social challenges. Furthermore, early temperament may modulate the influence of adolescent experiences on adult behavioral and adrenocortical function.
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稳定的行为抑制和糖皮质激素的产生作为寿命的预测指标。
影响因子：
2.9
作者：
Cavigelli SA;Ragan CM;Michael KC;Kovacsics CE;Bruscke AP
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.6
作者：
KAGAN, J;REZNICK, JS;SNIDMAN, N
通讯作者：
SNIDMAN, N