Toxicological status of nanoparticles: What we know and what we don't know.
Toxicological status of nanoparticles: What we know and what we don't know.
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DOI：
10.1016/j.cbi.2018.07.015
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发表时间：
2018-11-01
影响因子：
5.1
通讯作者：
Cummings BS
中科院分区：
文献类型：
--
作者：
Missaoui WN;Arnold RD;Cummings BS
纳米技术领域在过去几十年中呈指数级增长，部分原因是纳米颗粒在许多制造工艺中的使用，以及它们作为治疗疾病和药物输送的临床试剂的潜力。这创造了几个新的途径，通过这些途径，人类可以接触到纳米颗粒。不幸的是，评估纳米颗粒的毒理学影响(即纳米毒性)以及它们对人类健康和环境的可能危险的调查没有跟上它们使用的快速增长的步伐。这造成了知识上的差距，并对更多研究产生了实质性的需求。需要研究来帮助我们完成对纳米颗粒的毒性机制的理解，以及介导它们在细胞和组织中的分布和积累以及它们从体内消除的机制。本文综述了纳米粒子的各种应用、暴露途径、潜在毒性和对人类健康的危害。
The field of nanotechnology has grown exponentially during the last few decades, due in part to the use of nanoparticles in many manufacturing processes, as well as their potential as clinical agents for treatment of diseases and for drug delivery. This has created several new avenues by which humans can be exposed to nanoparticles. Unfortunately, investigations assessing the toxicological impacts of nanoparticles (i.e. nanotoxicity), as well as their possible risks to human health and the environment, have not kept pace with the rapid rise in their use. This has created a gap-in-knowledge and a substantial need for more research. Studies are needed to help complete our understanding of the mechanisms of toxicity of nanoparticles, as well as the mechanisms mediating their distribution and accumulation in cells and tissues and their elimination from the body. This review summarizes our knowledge on nanoparticles, including their various applications, routes of exposure, their potential toxicity and risks to human health.
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影响因子：
3.4
作者：
Alwi R;Telenkov S;Mandelis A;Leshuk T;Gu F;Oladepo S;Michaelian K
通讯作者：
Michaelian K
影响因子：
15
作者：
Brown, Sarah D.;Nativo, Paola;Smith, Jo-Ann;Stirling, David;Edwards, Paul R.;Venugopal, Balaji;Flint, David J.;Plumb, Jane A.;Graham, Duncan;Wheate, Nial J.
通讯作者：
Wheate, Nial J.
DOI：
10.2217/nnm.10.90
发表时间：
2010-12
期刊：
Nanomedicine (London, England)
影响因子：
--
作者：
Bhirde AA;Patel S;Sousa AA;Patel V;Molinolo AA;Ji Y;Leapman RD;Gutkind JS;Rusling JF
通讯作者：
Rusling JF
影响因子：
10.8
作者：
Burns AA;Vider J;Ow H;Herz E;Penate-Medina O;Baumgart M;Larson SM;Wiesner U;Bradbury M
通讯作者：
Bradbury M
影响因子：
3.7
作者：
Chen, Xianghong;Eksioglu, Erika A.;Wei, Sheng
通讯作者：
Wei, Sheng