Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats
Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats
复制标题
大鼠纹状体和小脑皮质与年龄和性别相关的代谢组改变
DOI：
10.1016/j.brainres.2013.02.033
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发表时间：
2013-04
期刊：
影响因子：
2.9
通讯作者：
Zhang, Xu
中科院分区：
文献类型：
--
作者：
Zhang, Xianrong;Wu, Junfang;Liu, Huilang;Zhang, Xu
为了明确运动相关皮层下核团的神经化学变化，加深对精细运动控制随年龄增长而逐渐减弱的神经生理学认识，采用基于高分辨魔角旋转1H-NMR波谱和偏最小二乘判别分析的代谢组学方法，研究了SD大鼠纹状体和小脑皮质代谢随年龄增长的变化。结果表明，老年大鼠这两个脑区肌醇和乳酸含量增加，牛磺酸含量减少。上述变化可能是神经元细胞改变的标志，其降低精细运动控制。此外，一些代谢产物具有性别相关性和区域特异性。老年雌性大鼠纹状体中谷氨酸减少，肌酸增加，而老年雄性大鼠纹状体中胆碱增加，小脑皮质中GABA增加。但进一步分析发现，除胆碱在雄性大鼠纹状体中的含量相对较低外，其余代谢产物在雄性大鼠和雌性大鼠之间无明显差异。以上结果提示能量代谢是年龄相关变化的一个重要指标，不仅雄性大鼠如此，雌性大鼠也是如此。
In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomic approach based on high resolution “magic angle spinning”1H-NMR spectroscopy and partial least squares-discriminant analysis. It was found that there were increased myo-inositol and lactate, and decreased taurine in these two brain regions of old rats. The above changes may be a marker for alterations of neuronal cells, which reduce fine motor control. Besides, some of the metabolites are gender-related and region-specific. Old female rats had decreased glutamate and increased creatine in striatum, while old male rats had increased choline in striatum, and increased GABA in cerebellar cortex, respectively. However, further analyses showed that most of the metabolites in male rats were not distinctively different with those of female ones except choline, which was in a relative lower level in striatum of male rats. All this results suggest that energy metabolism is an important indication of age-related change, which is not only in male, but also in female rats.
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影响因子：
3.5
作者：
Mingxia Sun;Yi Gu;Yumei Zhao;Chao Xu
通讯作者：
Mingxia Sun;Yi Gu;Yumei Zhao;Chao Xu
影响因子：
2.9
作者：
F. Fonnum;F. Walberg
通讯作者：
F. Fonnum;F. Walberg
影响因子：
3.5
作者：
A. Taranukhin;Elena Y. Taranukhina;P. Saransaari;I. M. Djatchkova;M. Pelto-huikko;S. Oja
通讯作者：
A. Taranukhin;Elena Y. Taranukhina;P. Saransaari;I. M. Djatchkova;M. Pelto-huikko;S. Oja
影响因子：
3.3
作者：
Gruber, S.;Pinker, K.;Moser, E.
通讯作者：
Moser, E.
影响因子：
5.7
作者：
Vernaleken, Ingo;Weibrich, Carsten;Gruender, Gerhard
通讯作者：
Gruender, Gerhard