White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination.
White Matter Plasticity in Anxiety: Disruption of Neural Network Synchronization During Threat-Safety Discrimination.
复制标题
DOI：
10.3389/fncel.2020.587053
复制
发表时间：
2020
影响因子：
5.3
通讯作者：
Casaccia P
中科院分区：
文献类型：
--
作者：
Liu J;Likhtik E;Shereen AD;Dennis-Tiwary TA;Casaccia P
最近的证据强调了白质束在典型和非典型行为中的重要性。白质随着学习、压力和社会经历的变化而动态变化。一些证据已经报道了精神疾病中的白质功能障碍，包括抑郁症、压力相关和焦虑相关的障碍。然而，人们对这些关联的机制基础仍知之甚少。在这里，我们概述了一个综合的观点，认为髓鞘可塑性异常和焦虑之间存在联系。根据现有的文献和不断涌现的新发现，我们认为在焦虑中，对威胁和安全学习的反应以及区分这两种刺激的能力可能会发生独特的变化。我们认为，这两种学习方式背后的神经回路中髓鞘可塑性的改变与焦虑相关障碍的出现有关，这是通过损害神经网络同步的机制来实现的。该模型的临床和翻译意义的焦虑症进行了讨论。
Recent evidence highlighted the importance of white matter tracts in typical and atypical behaviors. White matter dynamically changes in response to learning, stress, and social experiences. Several lines of evidence have reported white matter dysfunction in psychiatric conditions, including depression, stress- and anxiety-related disorders. The mechanistic underpinnings of these associations, however, remain poorly understood. Here, we outline an integrative perspective positing a link between aberrant myelin plasticity and anxiety. Drawing on extant literature and emerging new findings, we suggest that in anxiety, unique changes may occur in response to threat and to safety learning and the ability to discriminate between both types of stimuli. We propose that altered myelin plasticity in the neural circuits underlying these two forms of learning relates to the emergence of anxiety-related disorders, by compromising mechanisms of neural network synchronization. The clinical and translational implications of this model for anxiety-related disorders are discussed.
登录
查看更多内容
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
DOI：
10.1073/pnas.1907730116
发表时间：
2019-12-10
影响因子：
11.1
作者：
Chiappelli, Joshua;Rowland, Laura M.;Hong, L. Elliot
通讯作者：
Hong, L. Elliot
DOI：
10.1002/cne.22359
发表时间：
2010-07-15
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Cressman VL;Balaban J;Steinfeld S;Shemyakin A;Graham P;Parisot N;Moore H
通讯作者：
Moore H
影响因子：
16.2
作者：
Buzsáki G;Logothetis N;Singer W
通讯作者：
Singer W
影响因子：
7.7
作者：
Bonnefil, Valentina;Dietz, Karen;Liu, Jia
通讯作者：
Liu, Jia