Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder.
Neutrophil-to-Lymphocyte, Platelet-to-Lymphocyte and Monocyte-to-Lymphocyte Ratio in Bipolar Disorder.
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DOI：
10.3390/brainsci11010058
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发表时间：
2021-01-06
期刊：
影响因子：
3.3
通讯作者：
Aguglia A
中科院分区：
文献类型：
--
作者：
Fusar-Poli L;Natale A;Amerio A;Cimpoesu P;Grimaldi Filioli P;Aguglia E;Amore M;Serafini G;Aguglia A
背景：几种炎症假说已被提出来解释双相情感障碍（BD）的发病机制及其不同阶段。中性粒细胞与淋巴细胞（NLR）、血小板与淋巴细胞（PLR）和单核细胞与淋巴细胞（MLR）比率被认为是情绪发作的潜在外周生物标志物。方法：我们招募了294例双相障碍患者，其中143例正在经历（轻度）躁狂发作，151例处于抑郁期。抽取血样进行全血细胞计数。随后计算NLR、PLR和MLR。采用t检验来评估抑郁症和（轻度）躁狂患者血细胞计数的差异，然后计算回归模型。结果：中性粒细胞、血小板均值、血小板体积均值、NLR、PLR、MLR均显著高于（低）躁狂患者。逻辑回归显示，PLR可能是（轻度）躁狂的独立预测因子。结论：炎症指标的改变，尤其是PLR，可能解释了双相障碍患者（轻度）躁狂发作的发生和复发。由于炎症比率是经济且容易获得的炎症标志物，因此需要进一步的研究来更好地阐明它们作为双相障碍情绪发作的外周生物标志物的作用。
Background: Several inflammatory hypotheses have been suggested to explain the etiopathogenesis of bipolar disorder (BD) and its different phases. Neutrophil-to-lymphocyte (NLR), platelet-to-lymphocyte (PLR), and monocyte-to-lymphocyte (MLR) ratios have been proposed as potential peripheral biomarkers of mood episodes. Methods: We recruited 294 patients affected by BD, of which 143 were experiencing a (hypo)manic episode and 151 were in a depressive phase. A blood sample was drawn to perform a complete blood count. NLR, PLR, and MLR were subsequently calculated. A t-test was performed to evaluate differences in blood cell counts between depressed and (hypo)manic patients and a regression model was then computed. Results: Mean values of neutrophils, platelets, mean platelet volume, NLR, PLR, and MLR were significantly higher in (hypo)manic than depressed individuals. Logistic regression showed that PLR may represent an independent predictor of (hypo)mania. Conclusions: Altered inflammatory indexes, particularly PLR, may explain the onset and recurrence of (hypo)manic episodes in patients with BD. As inflammatory ratios represent economical and accessible markers of inflammation, further studies should be implemented to better elucidate their role as peripheral biomarkers of BD mood episodes.
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