Standardized assessment of bone micromorphometry around teeth following orthodontic tooth movement : A µCT split-mouth study in mice.
Standardized assessment of bone micromorphometry around teeth following orthodontic tooth movement : A µCT split-mouth study in mice.
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DOI：
10.1007/s00056-021-00336-9
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发表时间：
2022-11
影响因子：
1.7
通讯作者：
Becker, Kathrin
中科院分区：
文献类型：
--
作者：
Trelenberg-Stoll, Viktoria;Wolf, Michael;Busch, Caroline;Drescher, Dieter;Becker, Kathrin
关键词：
正畸牙齿移动后骨微形态变化的体积定量分析很难实现。本研究旨在验证和应用一种新的基于微计算机断层扫描（CT）的方法，该方法能够分割牙齿并定义牙根周围的标准化感兴趣体积（VOI），以评估局部骨微形态。用微型CT扫描3只未处理和14只经牵引处理的小鼠（用0.5N牵引右上磨牙11天;未处理的左上磨牙）的颌。对第一磨牙和牙槽骨进行分段，并在牙齿周围定义标准化的VOI。在VOI内评估每总体积的骨体积（BV/TV），并比较未处理（方法验证）和处理动物（方法应用）对侧部位之间的BV/TV值。组内相关系数为0.99，表明该方法具有较高的可靠性。在未给药动物中，Bland-Altman分析证实BV/TV分数相当（平均差异：−1.93，临界差异：1.91，Wilcoxon：p = 0.03）。在经免疫处理的动物中，与对照部位相比，试验部位的BV/TV值显著较低（试验部位：33.23% ± 5.74%，对照部位：41.33% ± 4.91%，Wilcoxon：p < 0.001）。在这项研究的范围内，这种新的方法证明了评估正畸治疗牙齿周围骨微形态的适用性。
Volumetric quantitative analyses of bone micromorphometry changes following orthodontic tooth movements are hardly standardizable. The present study aimed at validating and applying a novel microcomputed tomography (CT)-based approach that enables the segmentation of teeth and definition of a standardized volume of interest (VOI) around the roots to assess local bone micromorphometry. The jaws of 3 untreated and 14 orthodontically treated mice (protraction of the upper right molar for 11 days with 0.5 N; untreated left upper molar) were scanned with a micro-CT. The first molars and the alveolar bone were segmented, and a standardized VOI was defined around the teeth. The bone volume per total volume (BV/TV) was assessed within the VOI, and BV/TV values were compared between contralateral sites in both untreated (method validation) and treated animals (method application). The intraclass correlation coefficient of 0.99 revealed high reliability of the method. In the untreated animals, Bland–Altman analysis confirmed comparable BV/TV fractions (mean difference: −1.93, critical difference: 1.91, Wilcoxon: p = 0.03). In the orthodontically treated animals, BV/TV values were significantly lower at the test compared to the control site (test: 33.23% ± 5.74%, control: 41.33% ± 4.91%, Wilcoxon: p < 0.001). Within the limits of the study, the novel approach demonstrated the applicability to evaluate bone micromorphometry around teeth subjected to orthodontic treatment.
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影响因子：
3.3
作者：
Giavarina D
通讯作者：
Giavarina D
DOI：
10.1016/j.ajodo.2007.04.035
发表时间：
2008-12-01
影响因子：
3
作者：
Abass, Shaza K.;Hartsfield, James K., Jr.;Roberts, W. Eugene
通讯作者：
Roberts, W. Eugene
影响因子：
2.6
作者：
Milne, Trudy J.;Ichim, Ionut;Meikle, Murray C.
通讯作者：
Meikle, Murray C.
影响因子：
4.1
作者：
Müller, R;Van Campenhout, H;Rüegsegger, P
通讯作者：
Rüegsegger, P
影响因子：
--
作者：
VIGNERY, A;BARON, R
通讯作者：
BARON, R