Triggerable tough hydrogels for gastric resident dosage forms.
Triggerable tough hydrogels for gastric resident dosage forms.
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DOI：
10.1038/s41467-017-00144-z
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发表时间：
2017-07-25
影响因子：
16.6
通讯作者：
Traverso G
中科院分区：
文献类型：
--
作者：
Liu J;Pang Y;Zhang S;Cleveland C;Yin X;Booth L;Lin J;Lucy Lee YA;Mazdiyasni H;Saxton S;Kirtane AR;Erlach TV;Rogner J;Langer R;Traverso G
Systems capable of residing for prolonged periods of time in the gastric cavity have transformed our ability to diagnose and treat patients. Gastric resident systems for drug delivery, ideally need to be: ingestible, be able to change shape or swell to ensure prolonged gastric residence, have the mechanical integrity to withstand the forces associated with gastrointestinal motility, be triggerable to address any side effects, and be drug loadable and release drug over a prolonged period of time. Materials that have been primarily utilized for these applications have been largely restricted to thermoplastics and thermosets. Here we describe a novel set of materials, triggerable tough hydrogels, meeting all these requirement, supported by evaluation in a large animal model and ultimately demonstrate the potential of triggerable tough hydrogels to serve as prolonged gastric resident drug depots. Triggerable tough hydrogels may be applied in myriad of applications, including bariatric interventions, drug delivery, and tissue engineering. The use of drug delivery systems for the gastrointestinal tract has been faced with a number of drawbacks related to their prolonged use. Here, the authors develop a drug-loaded hydrogel with high strength to withstand long-term gastrointestinal motility and can be triggered to dissolve on demand.
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影响因子：
16.6
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Bin Imran A;Esaki K;Gotoh H;Seki T;Ito K;Sakai Y;Takeoka Y
通讯作者：
Takeoka Y
影响因子：
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Schmidt, Gudrun
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29.4
作者：
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通讯作者：
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通讯作者：
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