Resting-state functional connectivity of the human hippocampus in periadolescent children: Associations with age and memory performance.
Resting-state functional connectivity of the human hippocampus in periadolescent children: Associations with age and memory performance.
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DOI：
10.1002/hbm.25458
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发表时间：
2021-08-01
影响因子：
4.8
通讯作者：
Wilson TW
中科院分区：
文献类型：
--
作者：
Warren DE;Rangel AJ;Christopher-Hayes NJ;Eastman JA;Frenzel MR;Stephen JM;Calhoun VD;Wang YP;Wilson TW
海马体是陈述性（关系）记忆所必需的，形成海马体依赖性记忆的能力在青春期后期发展。海马依赖性记忆的这种发展轨迹可以反映内在功能性脑网络的成熟，但人类海马的静息状态功能连接（rs-FC）在青春期前儿童中并没有得到很好的表征。因此，在青春期前后测量海马rs-FC将填补一个空白，并且测试海马rs-FC与年龄和记忆的协方差可以为认知发展理论提供信息。在这里，我们使用基于种子的方法研究了健康儿童（N = 96; 59 F;年龄9-15岁）的横断面样本中的海马rs-FC，并将这些数据与NIH记忆测量，图片序列记忆测试（PSMT）和列表排序工作记忆测试（LSWMT）联系起来。预计PSMT比LSWMT更依赖于海马依赖性记忆。我们观察到海马rs-FC具有广泛的脑网络，包括颞叶，顶叶和额叶区域。这种模式与先前在年轻和老年样本中测量海马rs-FC的工作一致。我们还观察到海马rs-FC随年龄和海马依赖性记忆而非工作记忆的新的区域特异性变化。在费城神经发育队列中相似年龄健康儿童的第二个验证数据集中观察到与这些发现一致的证据。此外，交叉数据集分析表明海马rs-FC的可推广特性以及与年龄和记忆的协方差。我们的研究结果通过描述海马rs-FC和协方差与典型发育的青春期儿童的年龄和记忆联系了先前的工作，我们的观察结果表明支持海马依赖性记忆的大脑网络的发展轨迹。海马体对于正常的陈述性（关系）记忆是必要的，并且形成海马体依赖性记忆的能力在青春期后期继续发展。我们使用基于种子的方法研究了健康青少年的两个横截面样本（发现和验证）中海马的内在（静息）功能连接，并测量了海马功能连接与年龄和记忆表现的协方差。除了预测的海马功能连接模式外，我们还观察到海马功能连接随年龄和海马依赖性记忆的新的区域特异性变化。
The hippocampus is necessary for declarative (relational) memory, and the ability to form hippocampal‐dependent memories develops through late adolescence. This developmental trajectory of hippocampal‐dependent memory could reflect maturation of intrinsic functional brain networks, but resting‐state functional connectivity (rs‐FC) of the human hippocampus is not well‐characterized for periadolescent children. Measuring hippocampal rs‐FC in periadolescence would thus fill a gap, and testing covariance of hippocampal rs‐FC with age and memory could inform theories of cognitive development. Here, we studied hippocampal rs‐FC in a cross‐sectional sample of healthy children (N = 96; 59 F; age 9–15 years) using a seed‐based approach, and linked these data with NIH Toolbox measures, the Picture‐Sequence Memory Test (PSMT) and the List Sorting Working Memory Test (LSWMT). The PSMT was expected to rely more on hippocampal‐dependent memory than the LSWMT. We observed hippocampal rs‐FC with an extensive brain network including temporal, parietal, and frontal regions. This pattern was consistent with prior work measuring hippocampal rs‐FC in younger and older samples. We also observed novel, regionally specific variation in hippocampal rs‐FC with age and hippocampal‐dependent memory but not working memory. Evidence consistent with these findings was observed in a second, validation dataset of similar‐age healthy children drawn from the Philadelphia Neurodevelopment Cohort. Further, a cross‐dataset analysis suggested generalizable properties of hippocampal rs‐FC and covariance with age and memory. Our findings connect prior work by describing hippocampal rs‐FC and covariance with age and memory in typically developing periadolescent children, and our observations suggest a developmental trajectory for brain networks that support hippocampal‐dependent memory. The hippocampus is necessary for normal declarative (relational) memory, and the ability to form hippocampal‐dependent memories continues to develop through late adolescence. We studied the intrinsic (resting) functional connectivity of the hippocampus in two cross‐sectional samples (discovery and validation) of healthy periadolescent using a seed‐based approach, and measured the covariance of hippocampal functional connectivity with age and memory performance. In addition to predicted patterns of functional connectivity for hippocampus, we also observed novel, region‐specific variation in hippocampal functional connectivity with age and hippocampal‐dependent memory.
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影响因子：
5.7
作者：
Dosenbach NUF;Koller JM;Earl EA;Miranda-Dominguez O;Klein RL;Van AN;Snyder AZ;Nagel BJ;Nigg JT;Nguyen AL;Wesevich V;Greene DJ;Fair DA
通讯作者：
Fair DA
影响因子：
3.2
作者：
Chai XJ;Ofen N;Gabrieli JD;Whitfield-Gabrieli S
通讯作者：
Whitfield-Gabrieli S
影响因子：
3.6
作者：
DeMaster, Dana M.;Ghetti, Simona
通讯作者：
Ghetti, Simona
影响因子：
4
作者：
Brainerd, CJ;Stein, LM;Reyna, VF
通讯作者：
Reyna, VF
影响因子：
56.9
作者：
COHEN, NJ;SQUIRE, LR
通讯作者：
SQUIRE, LR