Resting state functional connectivity of the ventral attention network in children with a history of depression or anxiety.
Resting state functional connectivity of the ventral attention network in children with a history of depression or anxiety.
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DOI：
10.1016/j.jaac.2013.10.001
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发表时间：
2013-12
影响因子：
13.3
通讯作者：
Luby, Joan L.
中科院分区：
文献类型：
--
作者：
Sylvester, Chad M.;Barch, Deanna M.;Corbetta, Maurizio;Power, Jonathan D.;Schlaggar, Bradley L.;Luby, Joan L.
我们研究了儿童早期的抑郁症和焦虑症是否与腹侧注意网络（货车）的静息状态功能连接（RSFC）的变化有关，以及货车中的RSFC是否与这些疾病的注意力改变有关。这些疾病的重要临床特征，包括对新刺激的注意力变化和对负效价刺激的注意力变化（威胁/悲伤偏见），间接涉及货车。我们收集了8至12岁儿童的静息状态功能磁共振成像数据。对数据进行了体积删失，以减少亚毫米运动的伪影，从而获得了30名有抑郁和/或焦虑病史的儿童和42名无精神病史的儿童的可分析数据。我们比较了以下货车区域之间的成对RSFC：右腹外侧前额叶皮层（VLPFC），右后上级颞回（pSTG）和右腹侧缘上回（vSMG）。我们还收集了威胁偏见和当前临床症状的措施。与无精神病史的儿童相比，有抑郁和/或焦虑病史的儿童在货车区域中的RSFC减少。货车RSFC的大小与对威胁的注意力偏差指标相关，但与当前的抑郁、内化或外化症状无关。两组之间在同位左半球区域中未检测到RSFC变化。货车的中断可能是抑郁症和焦虑症的早期特征。货车的变化与注意力偏差和临床病史有关，但与当前的抑郁和焦虑症状无关。
We examined whether depression and anxiety disorders in early childhood were associated with changes in resting state functional connectivity (RSFC) of the ventral attention network (VAN), and whether RSFC in the VAN was associated with alterations in attention specific to these disorders. Important clinical features of these illnesses, including changes in attention toward novel stimuli and changes in attention to stimuli of negative valence (threat/sad bias), indirectly implicate the VAN. We collected resting state functional magnetic resonance imaging data in children aged 8 to 12 years. Data were volume censored to reduce artifact from submillimeter movement, resulting in analyzable data from 30 children with a history of depression and/or anxiety and 42 children with no psychiatric history. We compared pairwise RSFC among the following VAN regions: right ventro-lateral prefrontal cortex (VLPFC), right posterior superior temporal gyrus (pSTG), and right ventral supramarginal gyrus (vSMG). We also collected measures of threat bias and current clinical symptoms. Children with a history of depression and/or anxiety had reduced RSFC among the regions of the VAN compared to children with no psychiatric history. The magnitude of VAN RSFC was correlated with measures of attention bias toward threat but not with current depressive, internalizing, or externalizing symptoms. No RSFC changes were detected between groups among homotopic left hemisphere regions. Disruption in the VAN may be an early feature of depression and anxiety disorders. VAN changes were associated with attention bias and clinical history but not with current symptoms of depression and anxiety.
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影响因子：
--
作者：
Guyer, Amanda E.;Lau, Jennifer Y. F.;McClure-Tone, Erin B.;Parrish, Jessica;Shiffrin, Nina D.;Reynolds, Richard C.;Chen, Gang;Blair, R. J. R.;Leibenluft, Ellen;Fox, Nathan A.;Ernst, Monique;Pine, Daniel S.;Nelson, Eric E.
通讯作者：
Nelson, Eric E.
影响因子：
10.6
作者：
Kimble, M;Kaloupek, D;Deldin, P
通讯作者：
Deldin, P
影响因子：
--
作者：
Luby, Joan L.;Si, Xuemei;Belden, Andy C.;Tandon, Mini;Spitznagel, Ed
通讯作者：
Spitznagel, Ed
影响因子：
1.7
作者：
Gaffrey, Michael S.;Luby, Joan L.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
影响因子：
6.6
作者：
Gaffrey, Michael S.;Belden, Andy C.;Luby, Joan L.
通讯作者：
Luby, Joan L.