Early life stress sensitizes youth to the influence of stress-induced cortisol on memory for affective words.
Early life stress sensitizes youth to the influence of stress-induced cortisol on memory for affective words.
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DOI：
10.1002/dev.22105
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发表时间：
2021-07
影响因子：
2.2
通讯作者：
Lopez-Duran NL
中科院分区：
文献类型：
--
作者：
Kuhlman KR;Mayer SE;Vargas I;Lopez-Duran NL
早期生活压力（ELS）是一个公认的风险因素，精神病理学在整个生命周期。对压力诱导的皮质醇的认知脆弱性可以解释风险和弹性。目前的研究旨在阐明一个心理生物学的途径，连接压力，改变记忆中的情感词的青年和没有暴露于ELS。115名青少年（9-16岁，47%为女性）被随机分配到心理社会压力或对照组。紧接着压力或控制条件，参与者完成了情感词的记忆任务。应激前即刻至应激后25 min唾液皮质醇的变化可预测情感词的记忆。暴露于急性实验室应激导致HPA轴的激活。更大的皮质醇反应性与负价词的准确识别率较低。在暴露于ELS的年轻人中，对急性压力的更大的皮质醇反应与对焦虑和中性词的识别较差有关。皮质醇的急剧增加可能会干扰对记忆有影响的负价信息处理。暴露于高ELS的青年可能特别容易受到皮质醇的影响，这可能解释了压力导致高危青年精神病理学的一个途径。
Early life stress (ELS) is a well-established risk factor for psychopathology across the lifespan. Cognitive vulnerability to stress-induced cortisol may explain risk and resilience. The current study aimed to elucidate a psychobiological pathway linking stress to altered memory for affective words among youth with and without exposure to ELS. One hundred and fifteen youth (ages 9–16, 47% female) were randomized either to a psychosocial stressor or a control condition. Immediately following the stress or control condition, participants completed a memory task for affective words. Change in salivary cortisol from immediately before to 25 min after stress onset were used to predict memory for affective words. Exposure to the acute laboratory stressor led to activation of the HPA axis. Greater cortisol reactivity was associated with less accurate recognition of negative valence words. Among youth exposed to ELS, greater cortisol reactivity to acute stress was associated with poorer recognition of dysphoric and neutral words. Acute increases in cortisol may interfere with negatively-valenced information processing that has implications for memory. Youth exposed to high ELS may be particularly vulnerable to the effects of cortisol, which may explain one pathway through which stress leads to psychopathology among at-risk youth.
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影响因子：
2.2
作者：
Kuhlman KR;Robles TF;Haydon MD;Dooley L;Boyle CC;Bower JE
通讯作者：
Bower JE
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE
影响因子：
3.7
作者：
Ellenbogen, MA;Schwartzman, AE;Walker, CD
通讯作者：
Walker, CD
影响因子：
10.5
作者：
Kessler, Ronald C.;McLaughlin, Katie A.;Williams, David R.
通讯作者：
Williams, David R.