Psychomotor function in chronic daily Cannabis smokers during sustained abstinence.
Psychomotor function in chronic daily Cannabis smokers during sustained abstinence.
复制标题
持续戒酒期间，慢性每日吸烟者的精神运动功能。
DOI：
10.1371/journal.pone.0053127
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ramaekers JG
中科院分区：
文献类型：
--
作者：
Bosker WM;Karschner EL;Lee D;Goodwin RS;Hirvonen J;Innis RB;Theunissen EL;Kuypers KP;Huestis MA;Ramaekers JG
本研究在一个安全的研究单位评估了3周内连续监测戒烟的慢性每日大麻吸烟者的心理功能。我们假设，在长期、每日吸食大麻的人戒烟期间，心理表现会得到改善。在19名男性慢性每日大麻吸烟者中评估了关键跟踪（CTT）和分散注意力（DAT）任务的表现，这些吸烟者在基线和连续监测戒烟8天，14-16天和21-23天后。精神表现与对照组的非醉酒偶尔吸毒者进行了比较。CTT的临界频率（λc）和DAT的跟踪误差和控制损失是主要结局指标。结果显示，相对于对照组，慢性大麻吸烟者在基线期间在CTT（p<0.001）和DAT（p<0.001）上的表现受损。长期大麻吸烟者的心理表现在戒断3周后有所改善，但没有恢复到与对照组相当的表现。持续的大麻戒断适度改善了慢性每日大麻吸烟者的关键跟踪和分散注意力的表现，但与戒断3周后的对照组相比，仍然可以观察到损害。然而，组间差异需要谨慎解释，因为慢性吸烟者和对照组在教育、社会经济地位、生活方式和种族方面不匹配。
The present study assessed psychomotor function in chronic, daily cannabis smokers during 3 weeks continuously monitored abstinence on a secure research unit. We hypothesized that psychomotor performance would improve during abstinence of chronic, daily cannabis smokers. Performance on the critical tracking (CTT) and divided attention (DAT) tasks was assessed in 19 male chronic, daily cannabis smokers at baseline and after 8, 14–16 and 21–23 days of continuously monitored abstinence. Psychomotor performance was compared to a control group of non-intoxicated occasional drug users. Critical frequency (λc) of the CTT and tracking error and control losses of the DAT were the primary outcome measures. Results showed that chronic cannabis smokers’ performance on the CTT (p<0.001) and the DAT (p<0.001) was impaired during baseline relative to the comparison group. Psychomotor performance in the chronic cannabis smokers improved over 3 weeks of abstinence, but did not recover to equivalent control group performance. Sustained cannabis abstinence moderately improved critical tracking and divided attention performance in chronic, daily cannabis smokers, but impairment was still observable compared to controls after 3 weeks of abstinence. Between group differences, however, need to be interpreted with caution as chronic smokers and controls were not matched for education, social economic status, life style and race.
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DOI：
10.1002/(sici)1099-1077(1998110)13:2
发表时间：
1998-11-01
影响因子：
1.7
作者：
Neutel, I
通讯作者：
Neutel, I
影响因子：
7.6
作者：
Ramaekers, Johannes G.;Kauert, Gerhold;Moeller, Manfred R.
通讯作者：
Moeller, Manfred R.
影响因子：
120.7
作者：
Solowij, N;Stephens, RS;Vendetti, J
通讯作者：
Vendetti, J
影响因子：
6.7
作者：
Pope, H G Jr;Gruber, A J;Yurgelun-Todd, D
通讯作者：
Yurgelun-Todd, D
影响因子：
4.1
作者：
Ramaekers, J. G.;Kauert, G.;Moeller, M. R.
通讯作者：
Moeller, M. R.