Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka.
Associations Between Anxiety Symptoms and Health-Related Quality of Life: A Population-Based Twin Study in Sri Lanka.
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DOI：
10.1007/s10519-021-10051-1
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发表时间：
2021-07
影响因子：
2.6
通讯作者：
Rijsdijk FV
中科院分区：
文献类型：
--
作者：
Nas Z;Zavos HMS;Sumathipala A;Jayaweera K;Siribaddana S;Hotopf M;Rijsdijk FV
焦虑不仅关系到心理健康，还会对其他健康领域产生负面影响。然而，关于（a）这种关系的遗传和环境病因学;（B）病因学的性别差异和（c）非欧洲样本的研究有限。在本研究中，我们使用遗传双胞胎模型拟合分析，调查了焦虑症状的遗传和环境变异以及共变，以及健康相关生活质量（QoL）的八个组成部分，由简式健康调查（SF-36）测量。数据来自科隆博双胞胎和单胞胎研究（COTASS），这是一项在斯里兰卡进行的基于人群的样本，数据涉及双胞胎（N = 2921）和单胞胎（N = 1027）。焦虑和生活质量特征的个体差异表现出更多的共享环境（家庭）的影响，在妇女。男性没有表现出家族效应。焦虑与生活质量的所有八个组成部分呈负相关，主要是由重叠的独特（个人特定）的环境影响，在两性和重叠的共享环境影响的妇女。这是第一项在南亚人群中进行的支持心理健康状况不良与生活质量下降之间相关性的研究，突出了综合医疗服务的价值。协会主要是环境，在个人和家庭层面，这可能是治疗和干预的信息。在线版本包含补充材料，可通过10.1007/s10519-021-10051-1获得。
Anxiety not only concerns mental wellbeing but also negatively impacts other areas of health. Yet, there is limited research on (a) the genetic and environmental aetiology of such relationships; (b) sex differences in aetiology and (c) non-European samples. In this study, we investigated the genetic and environmental variation and covariation of anxiety symptoms and eight components of health-related quality of life (QoL), as measured by the short form health survey (SF-36), using genetic twin model fitting analysis. Data was drawn from the Colombo Twin and Singleton Study (COTASS), a population-based sample in Sri Lanka with data on twins (N = 2921) and singletons (N = 1027). Individual differences in anxiety and QoL traits showed more shared environmental (family) effects in women. Men did not show familial effects. Anxiety negatively correlated with all eight components of QoL, mostly driven by overlapping unique (individual-specific) environmental effects in both sexes and overlapping shared environmental effects in women. This is the first study in a South Asian population supporting the association between poor mental health and reduced QoL, highlighting the value of integrated healthcare services. Associations were largely environmental, on both individual and family levels, which could be informative for therapy and intervention. The online version contains supplementary material available at 10.1007/s10519-021-10051-1.
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DOI：
10.1192/bjp.bp.109.063529
发表时间：
2009-12
期刊：
The British journal of psychiatry : the journal of mental science
影响因子：
--
作者：
Ball HA;Sumathipala A;Siribaddana SH;Kovas Y;Glozier N;McGuffin P;Hotopf M
通讯作者：
Hotopf M
影响因子：
3.7
作者：
Keough, Meghan E.;Riccardi, Christina J.;Timpano, Kiara R.;Mitchell, Melissa A.;Schmidt, Norman B.
通讯作者：
Schmidt, Norman B.
影响因子：
3.7
作者：
Lee, Lewina O.;Gatz, Margaret;Prescott, Carol A.
通讯作者：
Prescott, Carol A.
影响因子：
6.6
作者：
Hinz, Andreas;Klein, Annette M.;Hilbert, Anja
通讯作者：
Hilbert, Anja
影响因子：
6.9
作者：
Chen, J.;Yu, J.;McGue, M.
通讯作者：
McGue, M.