Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice
Promotion of Hair Growth by Conditioned Medium from Extracellular Matrix/Stromal Vascular Fraction Gel in C57BL/6 Mice
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细胞外基质/基质血管组分凝胶条件培养基对 C57BL/6 小鼠毛发生长的促进作用
DOI：
10.1155/2020/9054514
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发表时间：
2020-06
影响因子：
4.3
通讯作者：
Zairong Wei
中科院分区：
文献类型：
--
作者：
Shune Xiao;Yurong Deng;Xiaojin Mo;Zhiyuan Liu;Dali Wang;Chengliang Deng;Zairong Wei
脂肪来源的干细胞（ADSC-）为基础的再生医学已经扩大到包括治疗脱发。然而，干细胞疗法仍然是一项相对较新的技术，其用于治疗脱发的报道很少。ADSCs通过多种生长因子和细胞因子的旁分泌作用发挥生物学功能。ADSCs条件培养基（ADSCs- cm）是一种富含生长因子和细胞因子的无细胞悬浮液，在刺激头发生长方面具有重要作用，在头发再生和头发生长方面具有令人鼓舞的结果。细胞外基质/基质血管部分凝胶（ECM/SVF-gel）是一种ADSC和脂肪天然细胞外基质富集产品，用于细胞治疗。在这项研究中，我们比较了来自ECM/ svf -凝胶（ECM/SVF-CM）和来自干细胞（SVF-CM）的CM对小鼠毛发生长的影响。与SVF-CM相比，ECM/SVF-CM通过促进真皮乳头细胞和凸起细胞的增殖、新生血管的形成和生长诱导，更能刺激毛发生长。因此，ECM/SVF-CM可能为促进头发生长提供了有效和改进的策略。这些数据为ECM/SVF-CM治疗脱发的临床应用提供了理论基础。
Adipose-derived stem cell- (ADSC-) based regenerative medicine has expanded to include the treatment of hair loss. However, stem cell therapy remains a relatively recent technique, and reports of its use for treating alopecia are rare. ADSCs exert biological functions via the paracrine actions of various growth factors and cytokines. Conditioned medium from ADSCs (ADSCs-CM) is a cell-free suspension rich in growth factors and cytokines that has demonstrated a significant role in stimulating hair growth, with encouraging outcomes in terms of hair regeneration and hair growth. Extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is an ADSC- and adipose native extracellular matrix-enriched product for cytotherapy. In this study, we compared the effects of CM from ECM/SVF-gel (ECM/SVF-CM) and from stem cells (SVF-CM) on hair growth in mice. ECM/SVF-CM stimulated hair growth more than SVF-CM, through promoting the proliferation of dermal papilla cells and cells in the bulge, neovascularization, and anagen induction. ECM/SVF-CM might, thus, provide an effective and improved strategy for promoting hair growth. These data provide a theoretical foundation for the clinical administration of ECM/SVF-CM for the treatment of hair loss.
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影响因子：
64.8
作者：
Rompolas, Panteleimon;Deschene, Elizabeth R.;Zito, Giovanni;Gonzalez, David G.;Saotome, Ichiko;Haberman, Ann M.;Greco, Valentina
通讯作者：
Greco, Valentina
影响因子：
3.6
作者：
Philips BJ;Grahovac TL;Valentin JE;Chung CW;Bliley JM;Pfeifer ME;Roy SB;Dreifuss S;Kelmendi-Doko A;Kling RE;Ravuri SK;Marra KG;Donnenberg VS;Donnenberg AD;Rubin JP
通讯作者：
Rubin JP
DOI：
--
发表时间：
2015-03
期刊：
Eplasty
影响因子：
--
作者：
H. Fukuoka;H. Suga
通讯作者：
H. Fukuoka;H. Suga
影响因子：
4.8
作者：
Vegesna, V;O'Kelly, J;Koeffler, HP
通讯作者：
Koeffler, HP
影响因子：
4.2
作者：
Cho, Yu Jin;Song, Hyeon Suk;Joo, Kyeung Min
通讯作者：
Joo, Kyeung Min