Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection.

Pain killers: the interplay between nonsteroidal anti-inflammatory drugs and Clostridioides difficile infection.
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DOI:
10.1016/j.mib.2021.11.011
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发表时间:
2022-03
影响因子:
5.4
通讯作者:
Zackular JP
Zackular JP
中科院分区:
生物学2区
文献类型:
--
作者:
Soto Ocaña J;Bayard NU;Zackular JP

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艰难梭菌是世界范围内医院感染的主要原因之一。与艰难梭菌感染(CDI)相关的发病率、严重程度和医疗费用的增加使这种病原体成为世界范围内紧迫的公共卫生威胁。影响CDI流行病学演变和感染临床结果的因素尚不清楚,但涉及宿主、微生物群和艰难梭菌之间的三方相互作用。除此之外,新出现的数据表明,饮食和药物等环境因素在CDI中的作用被低估了。本文就非甾体抗炎药(NSAIDs)和类二十烷类药物在CDI中的作用进行综述。
Clostridioides difficile is one of the leading causes of nosocomial infections worldwide. Increases in incidence, severity, and healthcare cost associated with C. difficile infection (CDI) have made this pathogen an urgent public health threat worldwide. The factors shaping the evolving epidemiology of CDI and impacting clinical outcomes of infection are not well understood, but involve tripartite interactions between the host, microbiota, and C. difficile. In addition to this, emerging data suggests an underappreciated role for environmental factors, such as diet and pharmaceutical drugs, in CDI. In this review, we discuss the role of nonsteroidal anti-inflammatory drugs (NSAIDs) and eicosanoids in CDI.
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