Maternal active asthma in pregnancy influences associations between polyunsaturated fatty acid intake and child asthma.
Maternal active asthma in pregnancy influences associations between polyunsaturated fatty acid intake and child asthma.
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DOI：
10.1016/j.anai.2021.06.012
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Carroll K
中科院分区：
文献类型：
--
作者：
Flom JD;Chiu YM;Cowell W;Kannan S;Ganguri HB;Coull BA;Wright RJ;Carroll K
产前多不饱和脂肪酸（PUFA）摄入对儿童哮喘影响的研究结果喜忧参半。不考虑重要的改变因素，如母亲哮喘或儿童性别，可能会导致发病。目的：在412对母子中，研究产前多不饱和脂肪酸摄入与儿童哮喘之间的关联是否受到产前活动性母亲哮喘或儿童性别的影响。使用Block 98食物频率调查问卷（在怀孕期间进行）估计能量调整的产前膳食和补充剂摄入的omega-3（n-3）和omega-6（n-6）PUFA。母亲报告的儿童哮喘前瞻性随访4.0±1.7年。使用具有PUFA（n-3，n-6，n-6/n-3比率）效应平滑项的广义加性模型来研究PUFA与儿童哮喘之间的关联，而不预先指定这些关系的形式，包括活动性母亲哮喘或儿童性别的效应修改。在母亲（40%黑人，31%西班牙裔）中，22%在怀孕期间患有活动性哮喘; 17.5%的儿童患有哮喘。母亲n-3-PUFA摄入量较低与儿童哮喘风险显著相关（p值（p）=0.03），特别是在患有活动性哮喘和n-3- PUFA摄入量较低的母亲的儿童中（p=0.01）。与男孩（p =0.30）相比，女孩（p=0.01）的这种负相关性更明显，无论母亲是否患有哮喘。对于n-6-PUFA和n6/n3比值，在中等摄入量范围内儿童哮喘的风险较低，在较高摄入量下风险增加（n-6-PUFA p=0.10，n6/n3比值p=0.13）。考虑到产前多不饱和脂肪酸摄入对儿童哮喘影响的因素，设计针对高危人群的干预策略具有一定意义。
Studies examining effects of prenatal polyunsaturated fatty acid (PUFA) intake on childhood asthma show mixed results. Inconsistencies may result from not accounting for important modifying factors such as maternal asthma or child sex. Objective: To examine whether associations between prenatal PUFA intake and childhood asthma are modified by prenatal active maternal asthma or child sex in 412 mother-child dyads. Energy-adjusted prenatal dietary and supplement intakes of omega-3 (n-3) and omega-6 (n-6) PUFAs were estimated using the Block98 Food Frequency Questionnaire, administered during pregnancy. Mothers reported asthma in children followed prospectively to 4.0±1.7 years. Generalized additive models with smooth terms for PUFA (n-3, n-6, n-6/n-3 ratio) effects were used to investigate associations between PUFAs and child asthma, without prespecifying the form of these relationships, including effect modification by active maternal asthma or child sex. Among mothers (40% black, 31% Hispanic), 22% had active asthma in pregnancy; 17.5% of children developed asthma. Lower maternal n-3-PUFA intake was significantly associated with risk of childhood asthma (p-value(p)=0.03), in particular among children of mothers with active asthma and low n-3- PUFA intake(p=0.01). This inverse association was more apparent in girls (p=0.01) compared to boys (p=0.30), regardless of maternal asthma status. For n-6-PUFA and the n6/n3 ratio, there was a lower risk of childhood asthma in the mid-range of intake and increased risk at higher intake (n-6-PUFA p=0.10, n6/n3 ratio p=0.13). Consideration of factors that modify effects of prenatal PUFA intake on childhood asthma has implications for designing intervention strategies tailored to impact those at greatest risk.
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期刊：
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影响因子：
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