How to assess regional and whole gut transit time with wireless motility capsule.
How to assess regional and whole gut transit time with wireless motility capsule.
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DOI：
10.5056/jnm.2014.20.2.265
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发表时间：
2014-04-30
影响因子：
3.4
通讯作者：
Rao SS
中科院分区：
文献类型：
--
作者：
Lee YY;Erdogan A;Rao SS
对胃肠道转运的评估提供了有关肠道生理学和病理生理学的有用信息。尽管有多种方法可用，但每种方法都有独特的优点和局限性。最近，一种类似于胶囊视频内窥镜的可摄入无线运动胶囊 (WMC) 已上市，可提供微创、标准化、无辐射和基于办公室的测试。该胶囊有 3 个传感器用于测量 pH、压力和温度，这些传感器提供的信息共同用于测量胃排空时间、小肠通过时间、结肠通过时间和全肠道通过时间。目前批准的该测试的适应症包括评估胃轻瘫中的胃排空、便秘中的结肠运输以及全身运动障碍的评估。罕见的胶囊滞留和故障是已知的限制，一些患者可能会遇到吞咽胶囊的困难。 WMC 的使用已被证实可用于评估胃肠道运输。转运时间的正常范围包括：胃排空（2-5小时）、小肠转运（2-6小时）、结肠转运（10-59小时）和全肠道转运（10-73小时）。除了避免使用多种内窥镜、放射学和功能性胃肠道检查外，WMC 还可以提供新的诊断，导致管理决策的改变，并帮助指导对疑似运动障碍患者进行进一步的集中检查。总之，WMC 代表了评估节段和整个肠道运输和蠕动方面的重大进步，并且可能被证明是全世界胃肠医生不可或缺的诊断工具。
Assessment of transit through the gastrointestinal tract provides useful information regarding gut physiology and patho-physiology. Although several methods are available, each has distinct advantages and limitations. Recently, an ingestible wireless motility capsule (WMC), similar to capsule video endoscopy, has become available that offers a less-invasive, standardized, radiation-free and office-based test. The capsule has 3 sensors for measurement of pH, pressure and temperature, and collectively the information provided by these sensors is used to measure gastric emptying time, small bowel transit time, colonic transit time and whole gut transit time. Current approved indications for the test include the evaluation of gastric emptying in gastroparesis, colonic transit in constipation and evaluation of generalised dysmotility. Rare capsule retention and malfunction are known limitations and some patients may experience difficulty with swallowing the capsule. The use of WMC has been validated for the assessment of gastrointestinal transit. The normal range for transit time includes the following: gastric emptying (2–5 hours), small bowel transit (2–6 hours), colonic transit (10–59 hours) and whole gut transit (10–73 hours). Besides avoiding the use of multiple endoscopic, radiologic and functional gastrointestinal tests, WMC can provide new diagnoses, leads to a change in management decision and help to direct further focused work-ups in patients with suspected disordered motility. In conclusion, WMC represents a significant advance in the assessment of segmental and whole gut transit and motility, and could prove to be an indispensable diagnostic tool for gastrointestinal physicians worldwide.
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