Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans.
Assessment of STAT4 Variants and Risk of Hepatocellular Carcinoma in Latin Americans and Europeans.
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DOI：
10.3390/cancers15184530
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发表时间：
2023-09-12
期刊：
影响因子：
5.2
通讯作者：
Debes, Jose D.
中科院分区：
文献类型：
--
作者：
Ayoub, Alan;Anugwom, Chimaobi M.;Prieto, Jhon;Balderramo, Domingo;Ferrer, Javier Diaz;Mattos, Angelo Z.;Arrese, Marco;Carrera, Enrique;Groothuismink, Zwier M. A.;Oliveira, Jeffrey;Boonstra, Andre;Debes, Jose D.
肝细胞癌（HCC）是一种常见且致命的肝癌类型，具有多种危险因素。这项研究探讨了一种特定的遗传变异体STAT 4 rs7574865与拉丁美洲和欧洲人群中HCC风险之间的联系。结果显示，在研究组中，这种遗传变异与HCC之间没有普遍关联。这项研究强调了研究不同人群的重要性，以更好地了解遗传因素对HCC风险的更广泛影响，这可能有助于制定更有效的策略来识别和管理高危人群。肝细胞癌（HCC）是世界范围内第三大癌症死亡原因。STAT 4 rs7574865基因变异与亚洲人群发生HCC的风险增加相关。然而，这种关联尚未在拉丁美洲进行研究，在欧洲人群中的评估也很差。这项病例对照研究调查了这些人群中STAT 4 rs7574865与HCC风险之间的关系。我们评估了来自六个拉丁美洲国家的七个医疗机构和一个荷兰机构的1060名个体（344名HCC和716名对照）的DNA样本。STAT 4 rs7574865单核苷酸多态性采用TaqMan基因分型法进行基因分型，并采用logistic回归分析。我们发现，在两个人群中，STAT 4的纯合风险等位基因（G）与HCC发生之间没有显著相关性，拉丁美洲人和欧洲人GG与TT的比值比（OR）分别为0.85（CI：0.48-1.52，p = 0.58）和0.81（CI：0.34-1.93，p = 0.67）。基于基础肝病，未发现危险等位基因与HCC之间的相关性。然而，我们发现欧洲血统的拉丁美洲人更有可能携带风险等位基因。我们的研究结果表明，STAT 4 SNP rs7574865不会影响拉丁美洲或欧洲人群发生HCC的风险，这突出了评估不同种族群体遗传风险因素和了解祖先对疾病遗传基础的可能影响的重要性。
Hepatocellular carcinoma (HCC) is a prevalent and fatal type of liver cancer with various risk factors. This study examines the connection between a specific genetic variant, STAT4 rs7574865, and HCC risk in Latin American and European populations. The results reveal no general association between this genetic variant and HCC in the studied groups. This study underscores the significance of researching diverse populations to gain a better understanding of the broader influence of genetic factors on HCC risk, which may aid in developing more effective strategies for identifying and managing high-risk individuals. Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. The STAT4 rs7574865 genetic variant has been associated with an increased risk of developing HCC in Asian populations. However, this association has not been studied in Latin America and is poorly assessed in European populations. This case-control study investigated the association between STAT4 rs7574865 and HCC risk in these populations. We evaluated DNA samples from seven medical institutions across six Latin American countries and one Dutch institution in 1060 individuals (344 HCC and 716 controls). STAT4 rs7574865 SNP was genotyped using TaqMan-genotyping assay and analyzed using logistic regression. We found no significant association between the homozygous risk allele (G) of STAT4 and HCC development in either population, with odds ratios (OR) for GG versus TT of 0.85 (CI: 0.48–1.52, p = 0.58) and 0.81 (CI: 0.34–1.93, p = 0.67) for Latin Americans and Europeans respectively. No correlation was found between the risk allele and HCC based on underlying liver disease. However, we found that Latin Americans of European ancestry were more likely to carry the risk allele. Our results suggest that the STAT4 SNP rs7574865 does not influence the risk of developing HCC in Latin American or European populations, highlighting the importance of evaluating genetic risk factors in various ethnic groups and understanding the possible influence of ancestry on the genetic basis of disease.
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影响因子：
4
作者：
Chao X;Wu J;Zhang W;Feng X;Zhao L;Huang F;Jiang C
通讯作者：
Jiang C
影响因子：
3.7
作者：
Chen K;Shi W;Xin Z;Wang H;Zhu X;Wu X;Li Z;Li H;Liu Y
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中国汉族人群的全基因组关联研究确定了系统性红斑狼疮的九个新易感位点
影响因子：
30.8
作者：
Han, Jian-Wen;Zheng, Hou-Feng;Zhang, Xue-Jun
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Zhang, Xue-Jun
HLA-DP/DQ和STAT4多态性与HBV感染结果和小型荟萃分析的关联。
影响因子：
3.7
作者：
Liao Y;Cai B;Li Y;Chen J;Tao C;Huang H;Wang L
通讯作者：
Wang L
影响因子：
3.2
作者：
Clark, Adam;Gerlach, Franziska;Velavan, Thirumalaisamy P.
通讯作者：
Velavan, Thirumalaisamy P.