Wireless, battery-free, and fully implantable electrical neurostimulation in freely moving rodents.
Wireless, battery-free, and fully implantable electrical neurostimulation in freely moving rodents.
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DOI：
10.1038/s41378-021-00294-7
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发表时间：
2021
影响因子：
7.9
通讯作者：
Gutruf P
中科院分区：
文献类型：
--
作者：
Burton A;Won SM;Sohrabi AK;Stuart T;Amirhossein A;Kim JU;Park Y;Gabros A;Rogers JA;Vitale F;Richardson AG;Gutruf P
植入式脑深部刺激（DBS）系统用于帕金森病和慢性疼痛等疾病的临床治疗。然而，DBS的长期疗效有限，慢性神经可塑性改变和相关治疗机制尚不清楚。通常在小动物模型中完成的基础和机制研究是困难的，因为需要慢性刺激器，目前需要经常处理测试对象以给电池供电的系统充电，或者专门设置来管理限制实验范例和损害洞察力的绳索。为了克服这些挑战，我们展示了一种完全可植入、无线、无电池的平台，该平台允许啮齿动物进行慢性DBS，并能够实时控制刺激参数。该设备能够在宽频率范围内提供双相脉冲刺激，并通过低阻抗表面工程铂电极进行恒压控制。该设备利用现成的组件，并具有定制电极的能力，以实现广泛的实用性和快速传播。该系统的有效性通过在体内读出刺激诱发的神经活动和对自由运动大鼠内侧前脑束的慢性刺激来证明，以引起特征性的头部运动超过36天。
Implantable deep brain stimulation (DBS) systems are utilized for clinical treatment of diseases such as Parkinson’s disease and chronic pain. However, long-term efficacy of DBS is limited, and chronic neuroplastic changes and associated therapeutic mechanisms are not well understood. Fundamental and mechanistic investigation, typically accomplished in small animal models, is difficult because of the need for chronic stimulators that currently require either frequent handling of test subjects to charge battery-powered systems or specialized setups to manage tethers that restrict experimental paradigms and compromise insight. To overcome these challenges, we demonstrate a fully implantable, wireless, battery-free platform that allows for chronic DBS in rodents with the capability to control stimulation parameters digitally in real time. The devices are able to provide stimulation over a wide range of frequencies with biphasic pulses and constant voltage control via low-impedance, surface-engineered platinum electrodes. The devices utilize off-the-shelf components and feature the ability to customize electrodes to enable broad utility and rapid dissemination. Efficacy of the system is demonstrated with a readout of stimulation-evoked neural activity in vivo and chronic stimulation of the medial forebrain bundle in freely moving rats to evoke characteristic head motion for over 36 days.
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影响因子：
4.6
作者：
Koo B;Koh CS;Park HY;Lee HG;Chang JW;Choi S;Shin HC
通讯作者：
Shin HC
影响因子：
16.6
作者：
Ausra J;Munger SJ;Azami A;Burton A;Peralta R;Miller JE;Gutruf P
通讯作者：
Gutruf P
影响因子：
14.8
作者：
Carlezon, William A., Jr.;Chartoff, Elena H.
通讯作者：
Chartoff, Elena H.
影响因子：
4.3
作者：
Cong, Peng;Ko, Wen H.;Young, Darrin J.
通讯作者：
Young, Darrin J.
DOI：
10.1109/tnsre.2019.2936739
发表时间：
2019-10-01
影响因子：
4.9
作者：
Bjanes, David A.;Moritz, Chet T.
通讯作者：
Moritz, Chet T.