Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager.
Three-dimensional fluorescence tomography of human breast tissues in vivo using a hand-held optical imager.
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DOI：
10.1088/0031-9155/58/5/1563
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发表时间：
2013-03-07
影响因子：
3.5
通讯作者：
Godavarty A
中科院分区：
文献类型：
--
作者：
Erickson SJ;Martinez SL;DeCerce J;Romero A;Caldera L;Godavarty A
使用非电离辐射的扩散光学成像是一种非侵入性方法，显示出对乳腺癌诊断的希望。手持式光学成像仪显示了该技术临床转化的潜力，但它们尚未用于3D断层扫描。在这里，人体乳腺组织在体内的三维断层扫描是第一次使用手持式光学成像仪与自动配准设施。对乳房几何形状进行模拟研究，以证明在完美（1：0）和不完美（100：1，50：1）荧光吸收对比度下使用手持式成像仪进行3D断层成像的可行性。使用1 μM ICG填充的体模靶在体内进行实验研究，该体模靶非侵入性地放置在乳房组织的皮瓣下方。结果表明，能够执行自动跟踪和共配准成像的人类乳腺组织（跟踪精度约为1厘米）。三维断层扫描结果表明，能够恢复一个单一的目标放置在2.5厘米的深度，从模拟（在1：0，100：1和50：1的对比度）和实验情况下，对实际的乳腺组织。正在进行的努力，以提高目标深度恢复进行通过实施的透射率成像的手持成像仪。
Diffuse optical imaging using non-ionizing radiation is a non-invasive method that shows promise towards breast cancer diagnosis. Hand-held optical imagers show potential for clinical translation of the technology, yet they have not been used towards 3D tomography. Herein, 3D tomography of human breast tissue in vivo is demonstrated for the first time using a hand-held optical imager with automated coregistration facilities. Simulation studies are performed on breast geometries to demonstrate the feasibility of 3D tomographic imaging using a hand-held imager under perfect (1:0) and imperfect (100:1, 50:1) fluorescence absorption contrast ratios. Experimental studies are performed in vivo using a 1 μM ICG filled phantom target placed non-invasively underneath the flap of the breast tissue. Results show the ability to perform automated tracking and coregistered imaging of human breast tissue (with tracking accuracy on the order of ~1 cm). Three-dimensional tomography results demonstrated the ability to recover a single target placed at a depth of 2.5 cm, from both the simulated (at 1:0, 100:1 and 50:1 contrasts) and experimental cases on actual breast tissues. Ongoing efforts to improve target depth recovery are carried out via implementation of transmittance imaging in the hand-held imager.
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影响因子：
3.5
作者：
Cerussi, Albert;Shah, Natasha;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.
DOI：
10.1073/pnas.0611058104
发表时间：
2007-03-06
影响因子：
11.1
作者：
Cerussi, Albert;Hsiang, David;Tromberg, Bruce J.
通讯作者：
Tromberg, Bruce J.
影响因子：
3.8
作者：
Culver, JP;Choe, R;Yodh, AG
通讯作者：
Yodh, AG
影响因子：
3.8
作者：
Joshi, Amit;Bangerth, Wolfgang;Sevick-Muraca, Eva M.
通讯作者：
Sevick-Muraca, Eva M.
影响因子：
3.8
作者：
Ge, Jiajia;Zhu, Banghe;Godavarty, Anuradha
通讯作者：
Godavarty, Anuradha