Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences.
Basal ganglia subcircuits distinctively encode the parsing and concatenation of action sequences.
复制标题
DOI：
10.1038/nn.3632
复制
发表时间：
2014-03
影响因子：
25
通讯作者：
Costa, Rui M.
中科院分区：
文献类型：
--
作者：
Jin, Xin;Tecuapetla, Fatuel;Costa, Rui M.
组块可以让大脑有效地组织记忆和行动。尽管基底节环路与动作组块有关，但关于单个元素是如何在神经水平上串联成行为序列的，人们知之甚少。利用小鼠学习快速动作序列的任务，我们发现了在基底节回路中将整个序列编码为单个动作的神经元活动。除了开始/停止活动信号序列解析外，我们还发现神经元在整个序列的执行过程中表现出抑制或持续的活动。这种持续的活动与单个序列元素的执行速度是一致的，与运动连接一致。基底节的直接和间接通路在序列启动过程中同时活跃，但在序列执行过程中表现不同，揭示了这些回路比先前假设的更复杂的功能组织。这些结果对于理解动作序列学习和执行过程中基底神经节的功能组织具有重要意义。
Chunking allows the brain to efficiently organize memories and actions. Although basal ganglia circuits have been implicated in action chunking, little is known about how individual elements are concatenated into a behavioral sequence at the neural level. Using a task where mice learn rapid action sequences, we uncovered neuronal activity encoding entire sequences as single actions in basal ganglia circuits. Besides start/stop activity signaling sequence parsing, we found neurons displaying inhibited or sustained activity throughout the execution of an entire sequence. This sustained activity covaried with the rate of execution of individual sequence elements, consistent with motor concatenation. Direct and indirect pathways of basal ganglia were concomitantly active during sequence initiation, but behaved differently during sequence performance, revealing a more complex functional organization of these circuits than previously postulated. These results have important implications for understanding the functional organization of basal ganglia during the learning and execution of action sequences.
登录
查看更多内容
影响因子：
14.5
作者：
BENECKE, R;ROTHWELL, JC;MARSDEN, CD
通讯作者：
MARSDEN, CD
影响因子：
64.8
作者：
Barnes, TD;Kubota, Y;Graybiel, AM
通讯作者：
Graybiel, AM
影响因子：
25
作者：
Boyden, ES;Zhang, F;Deisseroth, K
通讯作者：
Deisseroth, K
影响因子：
2.5
作者：
JURASKA, JM;WILSON, CJ;GROVES, PM
通讯作者：
GROVES, PM
影响因子：
2.5
作者：
Hampton, Cara M.;Sakata, Jon T.;Brainard, Michael S.
通讯作者：
Brainard, Michael S.