Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults.
Inverse correspondence between hippocampal perfusion and verbal memory performance in older adults.
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DOI：
10.1002/hipo.22080
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发表时间：
2013-03
期刊：
影响因子：
3.5
通讯作者：
Donahue, Manus J.
中科院分区：
文献类型：
--
作者：
Rane, Swati;Ally, Brandon A.;Hussey, Erin;Wilson, Tracy;Thornton-Wells, Tricia;Gore, John C.;Donahue, Manus J.
了解年龄相关病理学中不可逆组织损伤之前的生理变化对于优化可能预防或延迟认知衰退的治疗至关重要。脑灌注是一种严格调节的生理特性，与组织代谢和功能相关，并且在一系列认知障碍中已报告了异常（升高和降低）海马灌注。然而，海马体的大小和位置使灌注定量复杂化，因为许多灌注技术以海马体大小的量级或超过海马体大小的空间分辨率获取数据，并且因此在该区域中是次优的（特别是在存在海马体萎缩和血流减少的情况下）。在此，使用自定义动脉自旋标记采集和分析程序，在认知正常的健康老年人（n = 20;年龄= 67 ± 7岁）中检查海马灌注和萎缩之间的关系，作为记忆表现的函数，这些老年人具有不同的痴呆遗传风险。当控制海马体积时，发现尽管没有海马组织萎缩或白色疾病，海马灌注与记忆表现呈负相关（P = 0.04）。与非携带者相比，APOE-ε 4携带者的海马血流不对称性（左海马灌注-右海马灌注）显著增加（P = 0.04）。这些研究结果表明，灌注相关性更强，比组织容量与记忆性能在认知正常的老年人，而且这两个参数之间的相反趋势表明，神经元活动的升高，可能介导的神经炎症和/或兴奋/抑制失衡，可能与记忆性能的微小变化密切相关。
Understanding physiological changes that precede irreversible tissue damage in age-related pathology is central to optimizing treatments that may prevent, or delay, cognitive decline. Cerebral perfusion is a tightly regulated physiological property, coupled to tissue metabolism and function, and abnormal (both elevated and reduced) hippocampal perfusion has been reported in a range of cognitive disorders. However, the size and location of the hippocampus complicates perfusion quantification, as many perfusion techniques acquire data with spatial resolution on the order of or beyond the size of the hippocampus, and are thus suboptimal in this region (especially in the presence of hippocampal atrophy and reduced flow scenarios). Here, the relationship between hippocampal perfusion and atrophy as a function of memory performance was examined in cognitively normal healthy older adults (n = 20; age=67 ± 7 yr) with varying genetic risk for dementia using a custom arterial spin labeling acquisition and analysis procedure. When controlling for hippocampal volume, it was found that hippocampal perfusion correlated inversely (P = 0.04) with memory performance despite absent hippocampal tissue atrophy or white matter disease. The hippocampal flow asymmetry (left hippocampus perfusion–right hippocampus perfusion) was significantly (P = 0.04) increased in APOE-ε4 carriers relative to noncarriers. These findings demonstrate that perfusion correlates more strongly than tissue volume with memory performance in cognitively normal older adults, and furthermore that an inverse trend between these two parameters suggests that elevation of neuronal activity, possibly mediated by neuroinflammation and/or excitation/inhibition imbalance, may be closely associated with minor changes in memory performance.
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