Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers.
Association between Organophosphate Pesticide Exposure and Insulin Resistance in Pesticide Sprayers and Nonfarmworkers.
复制标题
农药喷洒者和非农业工人中有机磷农药暴露与胰岛素抵抗之间的关联。
DOI：
10.3390/ijerph17218140
复制
发表时间：
2020-11-04
影响因子：
--
通讯作者：
Kongtip P
中科院分区：
文献类型：
--
作者：
Seesen M;Lucchini RG;Siriruttanapruk S;Sapbamrer R;Hongsibsong S;Woskie S;Kongtip P
胰岛素抵抗是各种疾病的危险因素。据报道，长期接触有机磷是造成动物模型胰岛素抵抗的原因之一。这项横断面研究旨在评估农药喷雾者和非农业工人暴露于有机磷与胰岛素抵抗之间的关系。40-60岁的参与者，包括150名农药喷雾者和150名非农业工人，接受了采访和评估，以了解他们的胰岛素抵抗水平的稳态模型评估(HOMA-IR)。对37名喷雾工和46名非农工进行了晨尿二烷基磷酸盐(DAP)代谢物测定。除二乙基硫代磷酸酯(DETP；p=0.03)外，两组的DAP代谢物水平均无差异，喷雾器组的DAP代谢物水平较高。未观察到DAP代谢产物水平与HOMA-IR之间的显著关联。戴口罩接触农药与较低的二甲基代谢物相关(95%CI=−11.10，−0.17)。阅读农药标签(95%CI=−81.47，−14.99)和混配农药后洗手(95%CI=−39.97，−3.35)与较低的烷基磷酸二乙酯水平相关。总体而言，我们没有观察到农药喷雾者和普通人群中OP暴露与胰岛素抵抗之间的任何联系。然而，个人防护用品(PPE)的使用和工作实践与喷雾器中OP暴露水平有关。
Insulin resistance is a risk factor for various diseases. Chronic organophosphate exposure has been reported to be a cause of insulin resistance in animal models. This cross-sectional study aimed to evaluate the association between organophosphate exposure and insulin resistance in pesticide sprayers and nonfarmworkers. Participants aged 40–60 years, consisting of 150 pesticide sprayers and 150 nonfarmworkers, were interviewed and assessed for their homeostatic model assessment of insulin resistance (HOMA-IR) level. Organophosphate (OP) exposure was measured in 37 sprayers and 46 nonfarmworkers by first morning urinary dialkyl phosphate (DAP) metabolites. The DAP metabolite levels were not different in either group except for diethylthiophosphate (DETP; p = 0.03), which was higher in sprayers. No significant association was observed between DAP metabolite levels and HOMA-IR. Wearing a mask while handling pesticides was associated with lower dimethyl metabolites (95% CI = −11.10, −0.17). Work practices of reading pesticide labels (95% CI = −81.47, −14.99) and washing hands after mixing pesticide (95% CI = −39.97, −3.35) correlated with lower diethyl alkylphosphate level. Overall, we did not observe any association between OP exposure and insulin resistance in pesticide sprayers and the general population. However, personal protective equipment (PPE) utilization and work practice were associated with OP exposure level in sprayers.
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DOI：
10.1038/sj.jea.7500322
发表时间：
2004-05-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Bravo, R;Caltabiano, LM;Barr, DB
通讯作者：
Barr, DB
影响因子：
2.9
作者：
Choi, Jaesung;Choi, Ji-Yeob;Kang, Daehee
通讯作者：
Kang, Daehee
影响因子：
8.8
作者：
Acker, Carmine Ines;Nogueira, Cristina Wayne
通讯作者：
Nogueira, Cristina Wayne
DOI：
10.3390/ijerph8041061
发表时间：
2011-04
影响因子：
--
作者：
Bradman A;Castorina R;Barr DB;Chevrier J;Harnly ME;Eisen EA;McKone TE;Harley K;Holland N;Eskenazi B
通讯作者：
Eskenazi B
DOI：
10.1016/j.dsx.2017.12.004
发表时间：
2018-05-01
影响因子：
10
作者：
Dash, Deepak Kumar;Choudhury, Arun Kumar;Baliarsinha, Anoj Kumar
通讯作者：
Baliarsinha, Anoj Kumar