Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study.
Long term antipsychotic treatment does not alter metabolite concentrations in rat striatum: an in vivo magnetic resonance spectroscopy study.
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DOI：
10.1016/j.schres.2011.02.019
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发表时间：
2011-05
影响因子：
4.5
通讯作者：
Cecil, Kim M.
中科院分区：
文献类型：
--
作者：
Lindquist, Diana M.;Dunn, R. Scott;Cecil, Kim M.
质子磁共振波谱（MRS）的研究精神分裂症患者一般揭示减少水平的N-乙酰天冬氨酸（NAA）相比，健康对照组。这种减少是由于疾病还是用于治疗的药物仍然是一个悬而未决的问题。许多人类和动物研究试图确定抗精神病药物对NAA水平的影响，结果不一。大多数动物研究是离体研究，可能无法准确反映体内情况，人体研究的局限性包括既往或合并用药或其他混淆。为了克服这些局限性，我们通过饮用水给予10只大鼠/组0.2或2 mg/kg/天氟哌啶醇或10或30 mg/kg/天氯氮平，持续6个月。对照组大鼠饮用纯净水。在给药前和给药期间每月从主要包含右侧纹状体的64 μL体素中纵向收集6个月的质子MRS数据，并用于估计NAA、肌酸和胆碱的浓度。还计算了NAA、胆碱、肌醇和谷氨酸+谷氨酰胺与肌酸的比率。只有Cho/Cr比值显示出显著的时间-治疗效应（p=0.0285）。这些结果与以前的研究纹状体。然而，区域和特定疾病的影响仍未得到解决。
Proton magnetic resonance spectroscopy (MRS) studies of schizophrenic patients generally reveal reduced levels of N-acetyl aspartate (NAA) when compared with healthy controls. Whether this reduction is due to the disease or to the drugs used for treatment remains an open question. Numerous human and animal studies have attempted to determine the effects of antipsychotics on NAA levels with mixed results. The majority of the animal studies were ex vivo, which may not accurately reflect the in vivo situation, and limitations of the human studies include previous or concomitant medications or other confounds. To overcome these limitations, we dosed 10 rats/group for six months via drinking water with 0.2 or 2 mg/kg/day haloperidol or 10 or 30 mg/kg/day clozapine. Control rats received unadulterated water. Proton MRS data were collected longitudinally over the six month period from a 64 μL voxel containing primarily the right striatum prior to and monthly during drug administration and used to estimate the concentrations of NAA, creatine, and choline. Ratios of NAA, choline, inositol and glutamate+glutamine to creatine were also calculated. Only the Cho/Cr ratio showed a significant time-by-treatment effect (p=0.0285). These results are in agreement with previous studies of the striatum. However, regional and disease-specific effects remain unresolved.
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影响因子：
4.5
作者：
Bartzokis, George;Lu, Po H.;Stewart, Stephanie B.;Oluwadara, Bolanle;Lucas, Andrew J.;Pantages, Joanna;Pratt, Erika;Sherin, Jonathan E.;Altshuler, Lori L.;Mintz, Jim;Gitlin, Michael J.;Subotnik, Kenneth L.;Nuechterlein, Keith H.
通讯作者：
Nuechterlein, Keith H.
影响因子：
11
作者：
通讯作者：
--
DOI：
10.1007/s00406-003-0398-5
发表时间：
2003-02-01
影响因子：
4.7
作者：
Ende, G;Braus, DF;Henn, FA
通讯作者：
Henn, FA
影响因子：
7.6
作者：
Bustillo, J;Barrow, R;Galloway, MP
通讯作者：
Galloway, MP
影响因子：
4.5
作者：
Bustillo, J;Wolff, C;Valenzuela, CF
通讯作者：
Valenzuela, CF