Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study.
Lupin protein positively affects plasma LDL cholesterol and LDL:HDL cholesterol ratio in hypercholesterolemic adults after four weeks of supplementation: a randomized, controlled crossover study.
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DOI：
10.1186/1475-2891-12-107
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发表时间：
2013-08-01
影响因子：
5.4
通讯作者：
Jahreis G
中科院分区：
文献类型：
--
作者：
Bähr M;Fechner A;Krämer J;Kiehntopf M;Jahreis G
几项研究表明，羽扇豆蛋白对人类心血管危险因素有有利的影响。然而，这些研究使用了> 33克/天的相对较高的剂量，在生理条件下几乎不能食用。因此，我们研究了25 g/d羽扇豆蛋白分离物（LPI）对选定的心血管标志物和血清氨基酸的影响。共有33名高胆固醇血症受试者参加了一项随机、对照、双盲交叉研究。将LPI和活性对照乳蛋白分离物（MPI）掺入蛋白饮料中，并在8周内食用，间隔4周洗脱期。在基线和两种蛋白质干预8周后评估人体测量数据、血压和营养摄入。在基线、第4周和第8周采集血液样本。所有33例受试者均被纳入最终统计分析中，使用重复测量ANOVA和一般线性模型或使用线性混合模型。除LPI第4周HDL胆固醇升高（P ≤ 0.036）外，LPI和MPI干预组的人体测量参数、血压和血脂无差异。与基线相比，两种干预措施4周后，主要结局LDL胆固醇显著降低（P ≤ 0.008），而LDL：HDL胆固醇比值仅通过LPI降低（P = 0.003）。这些时间效应仅限于高胆固醇血症受试者，并在8周后消失。LPI治疗8 wk后血压下降（P ≤ 0.044）。与LPI相比，MPI第4周几乎所有血清氨基酸均较高，但在第8周则无此现象。LPI干预4周和8周后，大多数氨基酸保持不变。两种干预措施均导致8周后体重和体脂轻微但显著增加（P ≤ 0.045）。总之，25 g LPI至少在短期内可以有益地调节血浆LDL胆固醇。使用适当的饮食条件，提高消费者的依从性，避免能量摄入和身体成分的变化，羽扇豆蛋白可以积极影响心血管风险因素，特别是在高胆固醇血症患者中。ClinicalTrials.gov：NCT01304992
A couple of studies indicate a favorable impact of lupin protein on cardiovascular risk factors in humans. These studies, however, used relatively high doses of > 33 g/d, which can hardly be consumed under physiological conditions. Therefore, we investigated the effect of 25 g/d lupin protein isolate (LPI) on selected cardiovascular markers and on serum amino acids. A total of 33 hypercholesterolemic subjects participated in a randomized, controlled, double-blind crossover study. LPI and the active comparator milk protein isolate (MPI) were incorporated in protein drinks and consumed over 8 wk separated by a 4 wk washout period. Anthropometric data, blood pressure, and nutrient intake were assessed at baseline and after 8 wk of both protein interventions. Blood was sampled at baseline, wk 4 and wk 8. All 33 subjects were included in final statistical analyses using repeated measures ANOVA with the general linear model or using linear mixed model. Except for higher HDL cholesterol at wk 4 of LPI (P ≤ 0.036), anthropometric parameters, blood pressure, and plasma lipids did not differ among LPI and MPI intervention. Compared to baseline, the primary outcome LDL cholesterol was significantly reduced after 4 wk of both interventions (P ≤ 0.008), while LDL:HDL cholesterol ratio was decreased only by LPI (P = 0.003). These time effects were restricted to subjects with higher hypercholesterolemia and disappeared after 8 wk. Blood pressure was reduced after 8 wk of LPI (P ≤ 0.044). Almost all serum amino acids were higher at wk 4 but not at wk 8 of MPI compared to LPI. Following 4 wk and 8 wk of LPI intervention, most amino acids remained unchanged. Both interventions caused a slight, but significant rise in body weight and body fat after 8 wk (P ≤ 0.045). In conclusion, 25 g LPI can beneficially modulate plasma LDL cholesterol at least over short-term. Using appropriate dietetic conditions that improve consumer compliance and avoid changes in energy intake as well as in body composition, lupin protein could positively impact cardiovascular risk factors particularly in individuals with higher hypercholesterolemia. ClinicalTrials.gov: NCT01304992
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DOI：
10.1038/oby.2001.138
发表时间：
2001-11-01
期刊：
OBESITY RESEARCH
影响因子：
--
作者：
Anderson, JW;Konz, EC
通讯作者：
Konz, EC
生长猪对日粮补充 L-精氨酸反应的代谢组学分析
影响因子：
3.5
作者：
He, Qinghua;Kong, Xiangfeng;Wu, Yongning
通讯作者：
Wu, Yongning
影响因子：
158.5
作者：
ANDERSON, JW;JOHNSTONE, BM;COOKNEWELL, ME
通讯作者：
COOKNEWELL, ME
影响因子：
8.8
作者：
Parolini, Cinzia;Rigamonti, Elena;Chiesa, Giulia
通讯作者：
Chiesa, Giulia
影响因子：
5.2
作者：
Resta, Donatella;Boschin, Giovanna;Arnoldi, Anna
通讯作者：
Arnoldi, Anna