Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.

Relationships between dopamine D2/3 receptor availability and social-environmental factors in humans.
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DOI:
10.1016/j.neulet.2022.136463
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发表时间:
2022-02-06
影响因子:
2.5
通讯作者:
Matuskey D
Matuskey D
中科院分区:
医学4区
文献类型:
--
作者:
Calakos KC;Rusowicz A;Pittman B;Gallezot JD;Potenza MN;Cosgrove KP;Matuskey D

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社会因素与精神疾病的结果和大脑功能有关。在对[11 C]PHNO正电子发射断层扫描(PET)成像数据(n=70)的回顾性分析中,探讨了从美国社区调查(2014-2018)的社会探索者分析中获得的当地人群数据与多巴胺D2/3受体(D2/3R)可用性之间的关系。较大的本地人口规模和较低比例的人口与学士学位或更高的纹状体D2/3R的可用性显着相关,这表明生活在人口稠密的地区,教育资源较少,可能伴随着多巴胺能变化的压力源。未来的前瞻性,合作研究需要更好地了解所观察到的关系的确切病因。
Social factors are associated with psychiatric outcomes and brain function. Relationships between local population data obtained from Social Explorer analyses of the American Community Survey (2014–2018) and dopamine D2/3 receptor (D2/3R) availability were explored in this retrospective analysis of [11C]PHNO positron emission tomography (PET) imaging data (n=70). Larger local population size and lower percentage of the population with a bachelor’s degree or higher were significantly associated with higher striatal D2/3R availability, suggesting that living in a populous area with fewer educational resources may be accompanied by stressors with concomitant dopaminergic changes. Future prospective, collaborative studies are needed to better understand the precise etiology of the observed relationships.
DOI: 10.1016/j.neuroimage.2016.02.002
发表时间: 2016-04-15
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