Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.
Neuroimaging features of depression-frailty phenotype in older adults: a pilot study.
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老年人抑郁衰弱表型的神经影像学特征：一项试点研究。
DOI：
10.1017/s1041610223000066
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发表时间：
2023
影响因子：
7
通讯作者：
Diniz,BrenoS
中科院分区：
文献类型：
--
作者：
Shuster,Ethan;Miles,AmyE;Heyland,LindsayK;Calarco,Navona;Jeyachandra,Jerrold;Mansour,Salim;Voineskos,AristotleN;Steffens,DavidC;Nikolova,YuliyaS;Diniz,BrenoS
目的：虚弱和晚年抑郁症（LLD）往往共存，并共享一些结构性脑改变。我们的目的是研究LLD和脆弱性对大脑结构的联合作用。设计：横断面研究设置：学术健康中心参与者：31名参与者（14 LLD+脆弱和17从不抑郁+强大）测量：LLD被诊断为老年精神病医生根据精神障碍诊断和统计手册第5版单次发作或复发性抑郁症没有精神病的功能。使用FRAIL量表（0-5）评估虚弱，将受试者分为强健（0）、虚弱前期（1-2）和虚弱（3-5）。参与者接受T1加权磁共振成像，其中进行皮质下体积的协方差分析和皮质厚度值的顶点分析，以访问灰质的变化。参与者还进行了扩散张量成像，其中基于束的空间统计与各向异性分数和平均扩散值的逐体素统计分析一起使用，以评估白色物质（WM）的变化。（X，Y，Z）= −26，− 11，27）。相应的效果大小（f=0.808）是large.Conclusion：我们发现LLD+Frailty组与WM束内的显着微观结构变化相比，从未抑郁+健壮的个人。我们的研究结果表明，神经炎症负荷增加的可能性是老年人同时发生这两种疾病的潜在机制，也是抑郁-虚弱表型的可能性。
Objective:Frailty and late-life depression (LLD) often coexist and share several structural brain changes. We aimed to study the joint effect LLD and frailty have on brain structure.Design:Cross-sectional studySetting:Academic Health CenterParticipants:Thirty-one participants (14 LLD+Frail and 17 Never-depressed+Robust)Measurement:LLD was diagnosed by a geriatric psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition for single episode or recurrent major depressive disorder without psychotic features. Frailty was assessed using the FRAIL scale (0–5), classifying subjects as robust (0), prefrail (1–2), and frail (3–5). Participants underwent T1-weighted magnetic resonance imaging in which covariance analysis of subcortical volumes and vertex-wise analysis of cortical thickness values were performed to access changes in grey matter. Participants also underwent diffusion tensor imaging in which tract-based spatial statistics was used with voxel-wise statistical analysis on fractional anisotropy and mean diffusion values to assess changes in white matter (WM).Results:We found a significant difference in mean diffusion values (48,225 voxels; peak voxel: pFWER=0.005, MINI coord. (X,Y,Z) = −26,−11,27) between the LLD-Frail group and comparison group. The corresponding effect size (f=0.808) was large.Conclusion:We showed the LLD+Frailty group is associated with significant microstructural changes within WM tracts compared to Never-depressed+Robust individuals. Our findings indicate the possibility of a heightened neuroinflammatory burden as a potential mechanism underlying the co-occurrence of both conditions and the possibility of a depression–frailty phenotype in older adults.
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影响因子：
4.2
作者：
Kant IMJ;de Bresser J;van Montfort SJT;Aarts E;Verlaan JJ;Zacharias N;Winterer G;Spies C;Slooter AJC;Hendrikse J;BioCog Consortium
通讯作者：
BioCog Consortium
影响因子：
4
作者：
Oude Voshaar RC;Dimitriadis M;vandenBrink RHS;Aprahamian I;Borges MK;Marijnissen RM;Hoogendijk EO;Rhebergen D;Jeuring HW
通讯作者：
Jeuring HW
影响因子：
7.2
作者：
Brown, Patrick J.;Roose, Steven P.;Rutherford, Bret R.
通讯作者：
Rutherford, Bret R.
影响因子：
2.6
作者：
O'Donnell, Lauren J.;Westin, Carl-Fredrik
通讯作者：
Westin, Carl-Fredrik
影响因子：
5.4
作者：
Mayerl, Hannes;Stolz, Erwin;Freidl, Wolfgang
通讯作者：
Freidl, Wolfgang